Background: Individuals respond to statins differently due to genetic variations. One of the most significant enzymes involved in drug metabolism is CYP2D6 enzyme, coded by the CYP2D6 gene. Individuals who carry two non-functional alleles in this gene are considered as poor metabolizers (PMs). Recognizing poor metabolizers might help in preventing adverse effects of drugs. Objective: In this ...

Abstract Objectives Hydroxychloroquine (HCQ) has been used as an off label for the management of coronavirus disease (Covid-19) infection with other drugs. However, different genetic variants can affect metabolism HCQ leading to inter-individual differences in its efficacy. In this study, we investigated effects CYP2D6, CYP3A4 and CYP3A5 on risk Covid-19 among patients receiving controlling rhe...

Wild type genotypes ( CYP2D6 ) and their allelic variants have been described in a sample of Peruvian mestizo population. The global allele frequency was 0.015 for CYP2D6*3 0.051 CYP2D6*4 . percentages were 97% CYP2D6*1/*1 3.0% CYP2D6*1/*3 ; 90.60% , 8.55% CYP2D6*1/*4 0.85% CYP2D6*4/*4 frequencies the Lima subpopulations 0.022 0.010 Junin; 0.048, 0.060, 0.050 residents Lima, Junín, Tacna, respe...

Cytochrome P450 2D6 (CYP2D6) is primarily expressed in the liver and central nervous system. It known to be highly polymorphic nature. metabolizes several endogenous substrates such as anandamide (AEA). Concomitantly, it involved phase 1 metabolism of antidepressants, antipsychotics, other drugs. Research field phytocannabinoids (pCBs) has recently accelerated owing their legalization increasin...

Цель. Определение наблюдений, выходящих за пределы референсного диапазона; оценка частот разных типов метаболизма по CYP2D6 и их связь; изучение влияния генотипа cyp2d6 на стационарную нормированную дозу концентрацию (C/D) ВЛФ, ОДВ, суммарную антидепрессивную фракцию (АМ), а также отношение метаболита к исходному веществу (MPR); определение перспектив фенотипического определения активности цито...

Background: CYP2D6 is polymorphically expressed enzyme that show marked interindividual and interethnic variation. Phenotyping of CYP2D6 provides valuable information about real-time activity of this important drug-metabolizing enzymes through the use of specific probe drugs. The aim of this study was to identify the CYP2D6 oxidation phenotype with dextromethorphan (DEX) as a probe drug in Maza...

Background: Clomiphene Citrate (CC) is the most frequently administered drug for the treatment of female infertility [e.g. polycystic ovary syndrome (PCOS)]; which aims at restoring ovulation. Clomiphene is metabolized by CYP2D6, an important enzyme responsible for the metabolism of approximately 25% of clinically used drugs. CYP2D6 is very polymorphic and thought to result in inter- individual...