نتایج جستجو برای: cyp2c19 enzyme

تعداد نتایج: 242459  

Journal: :مجله دانشگاه علوم پزشکی مازندران 0
حمید بدلی hamid badali associate professor, invasive fungi research centre, department of medical mycology and parasitology, faculty of medicine, mazandaran university of medical sciences, sari, iranدانشیار، مرکز تحقیقات قارچ های تهاجمی، گروه انگل شناسی و قارچ شناسی پزشکی، دانشکده پزشکی، دانشگاه علوم پزشکی مازندران، ساری، ایران افسانه واعظی afsane vaezi phd student in medical mycology, student research committee, faculty of medicine, mazandaran university of medical sciences, sari, iranدانشجوی دکتری قارچ شناسی پزشکی، کمیته تحقیقات دانشجویی دانشگاه علوم پزشکی مازندران، ساری، ایران نرگس اصلانی narges aslani phd student in medical mycology, student research committee, faculty of medicine, mazandaran university of medical sciences, sari, iranدانشجوی دکتری قارچ شناسی پزشکی، کمیته تحقیقات دانشجویی دانشگاه علوم پزشکی مازندران، ساری، ایران نینا زاهدی nina zahedi msc in medical mycology, invasive fungi research centre, faculty of medicine, mazandaran university of medical sciences, sari, iranکارشناسی ارشد قارچ شناسی پزشکی، مرکز تحقیقات قارچ های تهاجمی، دانشکده پزشکی، دانشگاه علوم پزشکی مازندران، ساری، ایران محمدرضا شیران mohammad reza shiran associate professor, immunogenetic research center, faculty of medicine, mazandaran university of medical sciences, sari, iranساری: دانشگاه علوم پزشکی مازندران، دانشکده پزشکی

voriconazole is an antifungal triazole, approved for management of invasive fungal diseases in patients. it is absorbed during two hours and its serum levels will be above 90%, based on the underlying factors, when the drug is administered orally. voriconazole shows a propotional increase in an area under the plasma concentration-time curve (auc), with increasing dose. plasma protein binding of...

Background: Cytochrome P450 2C19 (CYP2C19) is a polymorphically expressed enzyme that shows marked interindividual and interethnic variation. CYP2C19*2 and CYP2C19*3 are the most frequently identified defective alleles in Orientals and Caucasian poor metabolizers (PM). The aim of this study was to investigate the frequencies of CYP2C19*1, CYP2C19*2 and CYP2C19*3 alleles and CYP2C19 genotypes in...

Journal: :research in molecular medicine 0
naghi shahabi-majd faculty of medicine, mazandaran university of medical sciences, sari, postal code: 48471-91971, mazandaran, iran mohammad bagher hashemi-sotehoh faculty of medicine, mazandaran university of medical sciences, sari, postal code: 48471-91971, mazandaran, iran baharak habashi faculty of medicine, mazandaran university of medical sciences, sari, postal code: 48471-91971, mazandaran, iran mohammad reza shiran faculty of medicine, mazandaran university of medical sciences, sari, postal code: 48471-91971, mazandaran, iran

background: cytochrome p450 2c19 (cyp2c19) is a polymorphically expressed enzyme that shows marked interindividual and interethnic variation. cyp2c19*2 and cyp2c19*3 are the most frequently identified defective alleles in orientals and caucasian poor metabolizers (pm). the aim of this study was to investigate the frequencies of cyp2c19*1, cyp2c19*2 and cyp2c19*3 alleles and cyp2c19 genotypes in...

Elham Khalili, Mehdi Mohammadi, Molouk Hadjibabaie, Sholeh Ebrahimpour,

Background: Cytochrome P450 2C19 (CYP2C19) is widely involved in the metabolism of some medications. On the other hand, recent studies have shown the contribution of the CYP2C19 polymorphisms to different malignancies. We aimed to investigate the association between CYP2C19 polymorphism and occurrence of hematological malignancies by comparing the phenotype distribution of this enzyme in patien...

Objective(s): Alteration in drug metabolism is very likely in diabetes mellitus. This study assessed changes in CYP2C19 enzymatic activity in the liver using omeprazole as a probe in the animal model of type II diabetes (T2DM) before and after treatment with metformin and cinnamon.Materials and Methods: Twenty-eight male Wistar rats were...

Alireza Salek Moghaddam, Iraj Milanian, Mahmood Hoormand, Nader Tajik, Negin Zand,

Cytochrome P450 2C19 (CYP2C19) plays an important role in the metabolism and elimination of a wide range of medications. The polymorphisms of this enzyme give rise to substantial inter-individual and inter-ethnic variability in drug excretion rates and final serum concentrations. For this reason, therapeutic re-sponses and adverse drug reactions may vary from one person to another. In this stud...

Journal: :Acta physiologica Hungarica 2012
G Nyírő G Inczédy-Farkas V Reményi A Gál Zs Pál Mária Judit Molnár

Clopidogrel is an inhibitor of platelet-aggregation used in the prevention of secondary stroke. The molecule is activated by the cytochrome P450 2C19 (CYP2C19) enzyme. The frequent CYP2C19*2 point mutation causes loss of enzyme function, a decreased (heterozygous form) or blocked (homozygous form) formation of the active molecule. Thus, for a patient harboring a mutated allele, clopidogrel does...

Journal: :BioTechniques 2000
X Y Wang R H Levy R J Ho

Cytochrome P450 2C19 (CYP2C19) is the enzyme responsible for the metabolism of a number of drugs, including anticonvulsants and antidepressants. We have developed a semi-quantitative competitive RT-PCR assay to estimate the degree of expression of the full-length CYP2C19 message. This assay used a known quantity of internally deleted CYP2C19 RNA to quantitate the RT-PCR products of the CYP2C19 ...

2014
Chao-Hung Kuo Chien-Yu Lu Hsiang-Yao Shih Chung- Jung Liu Meng-Chieh Wu Huang-Ming Hu Wen-Hung Hsu Fang-Jung Yu Deng-Chyang Wu

The known factors that have contributed to the decline of Helicobacter pylori (H. pylori ) eradication rate include antibiotic resistance, poor compliance, high gastric acidity, high bacterial load, and cytochrome P450 2C19 (CYP2C19) polymorphism. Proton pump inhibitor (PPI) is important in the eradication regimen. The principal enzyme implicated in the metabolism of PPIs is CYP2C19. The effect...

Journal: :Drug testing and analysis 2017
Tian Lan Ling-Jing Yuan Xiao-Xia Hu Quan Zhou Jun Wang Xiang-Xin Huang Da-Peng Dai Jian-Ping Cai Guo-Xin Hu

CYP2C19 is an important member of the cytochrome P450 (CYP450) enzyme super family and is responsible for clearing approximately 10% of commonly used clinical drugs that undergo phase I metabolism. Genetic polymorphisms of CYP2C19 significantly influence the efficacy and safety of some drugs, which might cause undesirable adverse effects or cure failure at standard dosages. The aim of this stud...

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