Objective : Infertility is the inability of a couple to conceive after one and half year of unprotected sex.Infertility is an inability of a person to reproduce, in its normal state or condition. Male infertility is considered as a major problem all over the world. The aim of this study was to investigate the association of the CYP1A1 polymorphisms with idiopathic non-obstructive azoospermia in...

background: this study aimed to compare the cytochrome p450 1a1 (cyp1a1) gene expression in the cord blood of infants born from mothers living in low- and high-air polluted areas. materials and methods: te study was conducted in spring 2012 in isfahan, the second large and air-polluted city in iran. the study comprised 60 neonates, consisting of 30 infants born from mothers residing in areas wi...

background: breast cancer is the first leading cause of cancer-related death in women. pesticides which are excessively used in northern iran are one of the most important risk factors for breast cancer incidence. the cytochrome p450 1a1 (cyp1a1) is a key enzyme in xenobiotics metabolism and snps of its coding gene has been verified to be important in cancer susceptibility. the aim of this stud...

Recent studies have examined the relationship between genetic polymorphisms of the human cytochrome P-4501A1 (CYP1A1) gene and lung cancer susceptibility. We have quantified genotypic frequencies and measured gene expression in the CYP1A1 gene within racially diverse groups in order to determine the relationship between genotype and transcriptional regulation of the CYP1A1 gene. Lymphocytes wer...

background: endometriosis is one of the most commonly encountered benign problems in gynaecology. it is frequently associated with chronic pelvic pain, dysmenorrhoea, menorrhagia and dyspareunia, which lead to infertility. we determined the possible association between cyp1a1 mspi and gstm1 null polymorphism in the pathogenesis of endometriosis. materials and methods: ninety seven cases of endo...

Cytochrome P450 1A1 (CYP1A1), like many monooxygenases, can produce reactive oxygen species during its catalytic cycle. Apart from the well-characterized xenobiotic-elicited induction, the regulatory mechanisms involved in the control of the steady-state activity of CYP1A1 have not been elucidated. We show here that reactive oxygen species generated from the activity of CYP1A1 limit the levels ...

The dioxin 2,3,7,8-tetrachlorodibenzo-para-dioxin (TCDD) induces phase I and II xenobiotic metabolizing enzymes (XME) which act sequentially to eliminate different classes of xenobiotics. The transcriptional effects of TCDD are generally mediated by the arylhydrocarbon receptor (AhR). We hypothesized that TCDD could also act indirectly, by increasing the activity of cytochrome P450 1A1 (CYP1A1)...

The human CYP1A1 gene is regulated by the aryl hydrocarbon receptor (AhR), and induction of CYP1A1 is known to play an important role in xenobiotic metabolism. To examine the regulation of human CYP1A1 in vivo, we created a transgenic mouse strain (Tg-CYP1A1(GFP)) expressing a chimeric gene consisting of the entire human CYP1A1 gene (15 kb) fused with a GFP reporter gene. The treatment of Tg-CY...

This study aimed to investigate the correlation of CYP1A1 and GSTM1 gene polymorphisms and environmental factors to familial aggregation of esophageal cancer (EC) among the Kazakh ethnic group in Xinjiang. CYP1A1 and GSTM1 gene polymorphisms were detected using peripheral blood from 86 subjects belonging to families with EC and 82 control subjects. Additionally, a questionnaire survey was condu...