نتایج جستجو برای: cyclooxygenase 1 and 2 enzyme
تعداد نتایج: 17525058 فیلتر نتایج به سال:
background: studies have emphasized the effect of trigonella foenum-graecum extract on the reduction of pain and inflammation. objective: in this research we investigated the mechanisms of trigonella foenum-graecum extract in reducing pain and inflammation induced by formalin. methods: male albino mice (weight 20 - 25 g) were evaluated through the injection of 2 microliters of formalin to the p...
introduction: it has been shown that the extract of elaeagnus angustifolia can inhibit inflammation and pain induced by formalin in mice and rats. the aim of the present study is to reach evaluations of possible cellular and molecular mechanisms of elaeagnus angustifolia extract in reducing pain and inflammation through examining the extract ability for inhibition of cyclooxygenase (cox) type 1...
Introduction: It has been shown that the extract of Elaeagnus angustifolia can inhibit inflammation and pain induced by formalin in mice and rats. The aim of the present study is to reach evaluations of possible cellular and molecular mechanisms of Elaeagnus angustifolia extract in reducing pain and inflammation through examining the extract ability for inhibition of cyclooxygenase (Cox) type ...
Background and Objective: Triterpenes could exert anti-inflammatory properties. The aim of this study was to evaluate the inhibitory activities of cycloartan triterpene derivatives extracted from Euphorbia with names as cycloartan-24-methylene3-ol(1), cycloartan-23-ene-3,25-diol(2), cycloartan-23-ene-25-methoxy-3-ol (3) and cycloartan-24-ene-3-ol (4) on cyclooxygenase-1(cox-1) activity. Mate...
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In this study, we focused on screening and simulating the interaction between anti-inflammatory proteins 50 compounds isolated from Millettia dielsiana Harms ex Diels. 39 out of that violated no Lipinski’s rule five were sorted as favorable for drug development selected studies further. Then, a molecular docking study into binding sites COX-1 COX-2 allowed shedding light mode these potential CO...
Introduction: Inflammation as the body's defense response is accompanied with various diseases. Prostaglandins are major mediators of inflammation produced by the cyclooxygenase enzymes. So inhibitors of these enzymes can be effective in treating inflammation. There are reports of inhibition of these enzymes by isatin derivatives to control inflammation. Isatin is a heterocyclic compound whose...
Aspirin eugenol ester (AEE) is a promising drug candidate, which is used for the treatment of inflammation, pain and fever and the prevention of cardiovascular diseases. This study focuses on the effect of AEE on five proteins which are related to inflammation and thrombosis, including cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), C-reactive protein (CRP), prothrombin (FII) and arachidona...
The prostaglandins are lipid mediators, discovered in the 1930s by von Euler in Sweden and Goldblatt in the United Kingdom. They are made by the bifunctional enzyme, cyclooxygenase, which has both cyclooxygenase and peroxidase activities in the same molecule. Prostaglandins are involved in physiological functions such as protection of the stomach mucosa, aggregation of platelets and regulation ...
Aspirin eugenol ester (AEE) is a promising drug candidate, which is used for the treatment of inflammation, pain and fever and the prevention of cardiovascular diseases. This study focuses on the effect of AEE on five proteins which are related to inflammation and thrombosis, including cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), C-reactive protein (CRP), prothrombin (FII) and arachidona...
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