cycloguanil pamoate was intramuscularly injected into semi-immune people living in the hyper-endemic malarias area. the results showed that a single dose of cycloguanil pamoate by intramuscular injection together with an oral dose of chloroquine, 10 mg/kg body weight, suppressed p. falciparum for at least 3 months and p. vivax for 5 months in bandar abbas, southern iran.

Cycloguanil pamoate is an antimalarial drug recently developed by Thompson et al. (1963) in the United States. It is closely allied to the existing drugs, proguanil and pyrimethamine, and when administered intramuscularly is slowly released and thus maintains an effective antiplasmodial blood level for a prolonged period. The advantages offered by a repository drug become obvious when considera...

one hundred one cases of urban cutaneous leishmaniasis from mashad and teh ran were placed under treatment with either one or two sim ultaneous standa rd doses of cycloguanil parnoate. out of 101 patients, 96 were followed until the 120th day; 31 (31 per cent ) recovered with in 60 days, ?3 ('3 per cent) recovered utter between 60 and i70 days, and 42 (42 per cent) did not respond. a higher rec...

The in vitro activity of cycloguanil was assessed against 86 African isolates of Plasmodium falciparum by a semi-micro assay system. A bimodal distribution of susceptibility patterns was observed, with 44% of the isolates being cycloguanil susceptible. Cycloguanil alone retains a high activity against the intraerythrocytic forms of some isolates and, together with its activity against the hepat...

BACKGROUND It is widely recognized that only a handful of drugs are available against soil-transmitted helminthiasis, all of which are characterized by a low efficacy against Trichuris trichiura, when administered as single doses. The re-evaluation of old, forgotten drugs is a promising strategy to identify alternative anthelminthic drug candidates or drug combinations. METHODOLOGY We studied...

Both the antimalarial prodrug proguanil and the gastric proton pump inhibitor omeprazole are substrates for cytochrome P450 (CYP)2C19 and CYP3A. However, the relative contribution of each enzyme to proguanil bioactivation to cycloguanil and to the metabolism of omeprazole, as well as their potential to interact, remains to be examined. The bioactivation of proguanil to its active metabolite cyc...

The Ala16Val+Ser108Thr (A16V+S108T) mutant of the Plasmodium falciparum dihydrofolate reductase (DHFR) is a key mutant responsible for cycloguanil-resistant malaria due to steric interaction between Val-16 and one of the C-2 methyl groups of cycloguanil. 4,6-Diamino-1,2-dihydrotriazines have been prepared, in which both methyl groups of cycloguanil are replaced by H or by H and an alkyl or phen...

DESCRIPTION TRELSTAR  DEPOT contains a pamoate salt of triptorelin, and triptorelin is a synthetic decapeptide agonist analog of luteinizing hormone releasing hormone (LHRH or GnRH) with greater potency than the naturally occurring LHRH. The chemical name of triptorelin pamoate is 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-serylL-tyrosyl-D-tryptophyl-L-leucyl-L-arginyl-L-prolylglycine amide (pam...