Biofilm formation and adherence of bacteria to host tissue are one of the most important virulence factors of methicillin-resistant strains of Staphylococcus aureus (MRSA). The number of resistant strains is seriously increasing during the past years and bacteria have become resistant, not only to methicillin, but also to other commonly used antistaphylococcal antibiotics. There is a great need...

A new series of copolyester chalcone derivatives were synthesised from 1, 3-bis (4-hydroxy-3methoxyphenyl) propenone (BHMPP) and 1(3, 5-dihydroxyphenyl)-3-(4-methoxyphenyl) propenone (DHPMPP) with adipoyl, suberoyl, azeloyl and sebacoyl chlorides by phase transfer catalysed polycondensation method. The microstructure of the repeating unit was confirmed by IR, 1 H and 13 C NMR. These copolyester...

The title compound, C(17)H(16)ClNO, was synthesized using a solvent-free method by reaction of 4-(dimethyl-amino)benzaldehyde with 4-chloro-acetophenone and NaOH. The chloro-phenyl ring makes a dihedral angle of 18.1 (3)° with the central propenone unit, while the (dimethyl-amino)phenyl group is disordered over two orientations of equal occupancies, which make dihedral angles with the central p...

In the title compound, C(16)H(11)BrO(3), the mol-ecules adopt an E configuration with respect to the C=C double bond of the propenone unit. The 13 non-H atoms of the benzodioxole and propenone units are approximately coplanar (r.m.s. deviation = 0.027 Å) and the bromo-benzene ring plane forms a dihedral angle of 10.8 (1)° to this plane. The structure is layered, with the mol-ecules forming a he...

The pyridyl and aryl rings in the title compound, C(16)H(16)N(2)O, which are located at the ends of the propenone unit, are inclined at an angle of 17.1 (1)° with respect to each other.

Abstract Under different concentrations of the base potassium deuteroxide KOD, progress reactions, such as enolization, D‐substitution, isomerization, and conformational changes diketopiperazine cyclo(L‐Pro‐L‐Xxx) cyclo(D‐Pro‐L‐Xxx) (Xxx = Phe, Tyr) in D 2 O solution, was investigated by 1 H nuclear magnetic resonance (NMR). Cyclo(L‐Pro‐L‐Xxx) is mostly isomerized to whereas only slightly even ...

The title compound, C22H20O, was synthesized by reacting 4-iso-propyl-benzaldehyde with 2-acetonaphtone by aldolic condensation under Claisen-Schmidt conditions. The mol-ecule consists of a naphthalene group and a benzene ring with a pendant isopropyl moiety, both rings bound by a propenone linker. The naphthalene ring system is almost planar [maximum deviation from the least-squares plane = 0....

The reaction of 5,6-(2,2-dimethyl-chroman-yl)-2-hy-droxy-4-meth-oxy-acetophenone and 3,4-bis-(meth-oxy-meth-yloxy)benzaldehyde affords the intense orange title chalcone derivative, C(25)H(30)O(8). The two benzene rings are connected through a -C(=O)-CH=CH- (propenone) unit, which is in an E conformation; the ring with the hy-droxy substitutent is aligned at 19.5 (2)° with respect to this unit, ...

The addition of an aqueous solution diketopiperazine cyclo(Pro-Xxx) (Xxx: amino acid residue) to (?)-epigallocatechin-3-O-gallate (EGCg) led precipitation the complex EGCg and cyclo(Pro-Xxx). molecular capture abilities using were evaluated by ratio amount included in precipitates with that total used. Stronger hydrophobicity side chain residue a higher ability. Furthermore, ability decreased w...