نتایج جستجو برای: cyclin b1

تعداد نتایج: 41655  

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2002
Tadahiro Nozoe Daisuke Korenaga Akira Kabashima Takefumi Ohga Hiroshi Saeki Keizo Sugimachi

PURPOSE Cyclin B1 plays an important role as a mitotic cyclin in the G(2)-M phase transition during the cell cycle. The aim of the present study was to elucidate the biological significance of cyclin B1 expression in squamous cell carcinoma (SCC) of the esophagus. EXPERIMENTAL DESIGN We analyzed immunohistochemically the expression of cyclin B1 in the tumor specimens from 120 patients with SC...

Journal: :Current Biology 2007
Delquin Gong Joseph R. Pomerening Jason W. Myers Christer Gustavsson Joshua T. Jones Angela T. Hahn Tobias Meyer James E. Ferrell

Mitosis is thought to be triggered by the activation of Cdk-cyclin complexes. Here we have used RNA interference (RNAi) to assess the roles of three mitotic cyclins, cyclins A2, B1, and B2, in the regulation of centrosome separation and nuclear-envelope breakdown (NEB) in HeLa cells. We found that the timing of NEB was affected very little by knocking down cyclins B1 and B2 alone or in combinat...

Journal: :Molecular biology of the cell 2007
Anna M Bentley Guillaume Normand Jonathan Hoyt Randall W King

The mitotic cyclins promote cell division by binding and activating cyclin-dependent kinases (CDKs). Each cyclin has a unique pattern of subcellular localization that plays a vital role in regulating cell division. During mitosis, cyclin B1 is known to localize to centrosomes, microtubules, and chromatin. To determine the mechanisms of cyclin B1 localization in M phase, we imaged full-length an...

Journal: :Cell 2012
Silvia D.M. Santos Roy Wollman Tobias Meyer James E. Ferrell

Mitosis is triggered by the activation of Cdk1-cyclin B1 and its translocation from the cytoplasm to the nucleus. Positive feedback loops regulate the activation of Cdk1-cyclin B1 and help make the process irreversible and all-or-none in character. Here we examine whether an analogous process, spatial positive feedback, regulates Cdk1-cyclin B1 redistribution. We used chemical biology approache...

2007
Anna M. Bentley Guillaume Normand Jonathan Hoyt Randall W. King

The mitotic cyclins promote cell division by binding and activating cyclin-dependent kinases (CDKs). Each cyclin has a unique pattern of subcellular localization that plays a vital role in regulating cell division. During mitosis, cyclin B1 is known to localize to centrosomes, microtubules, and chromatin. To determine the mechanisms of cyclin B1 localization in M phase, we imaged full-length an...

2018
Bernhard Strauss Andrew Harrison Paula Almeida Coelho Keiko Yata Magdalena Zernicka-Goetz Jonathon Pines

There is remarkable redundancy between the Cyclin-Cdk complexes that comprise the cell cycle machinery. None of the mammalian A-, D-, or E-type cyclins are required in development until implantation, and only Cdk1 is essential for early cell divisions. Cyclin B1 is essential for development, but whether it is required for cell division is contentious. Here, we used a novel imaging approach to a...

2000
Jean-Charles Soria Se Jin Jang Fadlo R. Khuri Khaled Hassan Diane Liu Waun Ki Hong Li Mao

Cyclin B1 is a key molecule for G2-M-phase transition during the cell cycle and is overexpressed in various tumor types. However, the expression status of cyclin B1 in lung cancer and its clinical significance remain unknown. We used immunohistochemistry studies to examine the expression of cyclin B1 in 77 non-small cell lung cancer specimens from patients with histological stage I disease. All...

Journal: :Cancer research 2000
J C Soria S J Jang F R Khuri K Hassan D Liu W K Hong L Mao

Cyclin B1 is a key molecule for G2-M-phase transition during the cell cycle and is overexpressed in various tumor types. However, the expression status of cyclin B1 in lung cancer and its clinical significance remain unknown. We used immunohistochemistry studies to examine the expression of cyclin B1 in 77 non-small cell lung cancer specimens from patients with histological stage I disease. All...

Journal: :Molecular cancer therapeutics 2007
Lourdes A Gomez Alicia de Las Pozas Teresita Reiner Kerry Burnstein Carlos Perez-Stable

Chemotherapeutic drugs ideally should take advantage of the differences between transformed and normal cells and induce apoptosis only in cancer cells. One such difference may be the overexpression of cyclin B1 protein in cancer cells, which is required for the proper progression through mitosis. Previously, we showed that treatment of human prostate cancer cells with 2-methoxyestradiol (2-ME) ...

Journal: :International journal of clinical and experimental pathology 2014
Tingyuan Huang Size Chen Hongyu Han Huadan Li Zhizhou Huang Jianming Zhang Qiangbin Yin Xiaojie Wang Xiaojiao Ma Peijuan Dai Danping Duan Fei Zou Xuemei Chen

Hsp90α (heat shock protein 90α), one of the important molecular chaperones in cancer cell signal transduction, has been a new candidate target for cancer therapy. Cyclin B1, the client protein of Hsp90α, plays a key role as a mitotic cyclin in the G2-M phase transition during the cell cycle progression. However, the relationship between the level of HSP90α and cyclin B1, the location of Hsp90α ...

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