background: routinely collected data from tuberculosis surveillance system can be used to investigate and monitor the irregularities and abrupt changes of the disease incidence. we aimed at using a hidden markov model in order to detect the abnormal states of pulmonary tuberculosis in iran. methods: data for this study were the weekly number of newly diagnosed cases with sputum smear-positive p...

a bstract background: recent attempts have been focused on employing chemical and natural supplemental agents for treatment of cyclic mastalgia. among various agents, the potential effects of vitamins remain questionable. in the present study, we examined the efficacy of two types of these vitamin supplements (vitamin e and vitamin b6) in improving pain severity in cyclic mastalgia.   materials...

background : nonmyeloablative chemotherapy followed by adoptive immunotherapy is an attractive strategy for depleting regulatory t cells in the host. however, its efficacy is transient. here, we aim to investigate whether cyclic chemoim- munotherapy has therapeutic efficacy against cancer. methods :we examined the efficacy of cyclic chemoimmunotherapy with cyclophos- phamide and adoptively tran...