the internal mammary artery (ima) is currently the preferred conduit for myocardial revascularization. however, pre-operative vasospasm and a hypoperfusion state during maximal exercise may limit its use as a bypass graft. the mechanism of spasm has not been clearly defined. since β-adrenoceptor activation plays a major role in vasorelaxation, the present study was carried out to investigate th...

The coupling between myocardial beta-adrenergic receptors, adenylate cyclase activity, and the in vivo cardiac response to catecholamines is controversial in hyperthyroidism. The possibility of species differences in beta-adrenoceptor regulation after thyroxine treatment was studied in dogs and in rats. In dogs instrumented with a left ventricular (LV) pressure micromanometer, hyperthyroidism w...

A convenient and efficient radiosynthesis of no-carrier-added [123I]labeled (-)iodocyanopindolol, (-)-[123I]ICYP, a high affinity beta adrenergic antagonist, is described. (-)-[123I]ICYP was synthesized by a modified chloramine-T radioiodination of (-)cyanopindolol followed by a novel reversed-phase HPLC purification that provided the radiopharmaceutical as a directly injectable solution. The t...

An acute and potentially life-threatening complication associated with the recreational use of the 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) is hyperthermia. In the present study, Sprague-Dawley rats treated with MDMA (40 mg/kg s.c.) responded with a significant increase (maximal at 1 h) in rectal and skeletal muscle temperatures that lasted for at least 3 h post-treatment. Hypophysecto...

The nomenclature of the Adrenoceptors has been agreed by NC-IUPHAR Subcommittee on [64, 194]. Adrenoceptors, α1 three α1-adrenoceptor subtypes α1A, α1B and α1D are activated endogenous agonists (-)-adrenaline (-)-noradrenaline. -(-)phenylephrine, methoxamine cirazoline prazosin doxazosin antagonists considered selective for α1- relative to α2-adrenoceptors. [3H]prazosin [125I]HEAT (BE2254) rela...

The internal mammary artery (IMA) is currently the preferred conduit for myocardial revascularization. However, pre-operative vasospasm and a hypoperfusion state during maximal exercise may limit its use as a bypass graft. The mechanism of spasm has not been clearly defined. Since β-adrenoceptor activation plays a major role in vasorelaxation, the present study was carried out to investigate th...

removed. air dried. incubated in 7 X 1 0 I ' M-l"l-~abclkd cyanopindolol (CY P). washed, rapidly dried and subjected to autoradiography t o detect the presence of /3-adrenergic receptors [ 8 I. Autoradiography of polyester filter replicas after fusion ot COS cells with spheroplasts containing pPAR revealed punctate areas with high density "'I-CYP binding, consistent with induction o f /3-adrcne...