نتایج جستجو برای: cuznsod

تعداد نتایج: 245  

Journal: :Stroke 2006
Gary L Baumbach Sean P Didion Frank M Faraci

BACKGROUND AND PURPOSE Reactive oxygen species are believed to be an important determinant of vascular growth. We examined effects of genetic deficiency of copper-zinc superoxide dismutase (CuZnSOD; SOD1) on structure and function of cerebral arterioles. METHODS Systemic arterial pressure (SAP) and cross-sectional area of the vessel wall (CSA) and superoxide (O2-) levels (relative fluorescenc...

Journal: :Free radical biology & medicine 2014
Krupa Savalia Devika S Manickam Erin G Rosenbaugh Jun Tian Iman M Ahmad Alexander V Kabanov Matthew C Zimmerman

Excessive production of superoxide (O2(-)) in the central nervous system has been widely implicated in the pathogenesis of cardiovascular diseases, including chronic heart failure and hypertension. In an attempt to overcome the failed therapeutic impact of currently available antioxidants in cardiovascular disease, we developed a nanomedicine-based delivery system for the O2(-)-scavenging enzym...

Journal: :Journal of atherosclerosis and thrombosis 2011
Norio Ishigami Kikuo Isoda Takeshi Adachi Tomiharu Niida Takehiko Kujiraoka Daihiko Hakuno Harumi Kondo Masatoshi Kusuhara Fumitaka Ohsuzu

AIM The anti-oxidant enzyme copper/zinc superoxide dismutase (CuZnSOD) metabolizes superoxide anion (O(2)(-)) in vascular cells. However, the role of CuZnSOD in vascular injury remains poorly understood. METHODS Using CuZnSOD-deficient (CuZnSOD(-/-)) mice and wild-type (WT) mice, we investigated morphometric changes and the role of O(2)(-) in vascular remodeling after femoral artery injury in...

Journal: :Hypertension 2006
Sean P Didion Dale A Kinzenbaw Laura I Schrader Frank M Faraci

The goal of this study was to test the hypothesis that loss of a single copy of the gene for CuZn superoxide dismutase (CuZnSOD) increases vascular superoxide levels and produces vascular dysfunction with aging. Responses of carotid arteries from young (7 months) and old (22 to 24 months of age) heterozygous CuZnSOD-deficient (CuZnSOD(+/-)) mice and their wild-type (CuZnSOD(+/+)) littermates we...

Journal: :Circulation research 2002
Sean P Didion Michael J Ryan Lisa A Didion Pamela E Fegan Curt D Sigmund Frank M Faraci

Increased superoxide is thought to play a major role in vascular dysfunction in a variety of disease states. Superoxide dismutase (SOD) limits increases in superoxide; however, the functional significance of selected isoforms of SOD within the vessel wall are unknown. We tested the hypothesis that selective loss of CuZnSOD results in increased superoxide and altered vascular responsiveness in C...

Journal: :Cancer research 2002
Ying Zhang Weiling Zhao Hannah J Zhang Frederick E Domann Larry W Oberley

Copper zinc superoxide dismutase (CuZnSOD) is an essential primary antioxidant enzyme that converts superoxide radical to hydrogen peroxide and molecular oxygen in the cytoplasm. Cytosolic glutathione peroxidase (GPx) converts hydrogen peroxide into water. The overall goal of the present study was to explore the possible role of the antioxidant enzyme CuZnSOD in expression of the malignant phen...

Journal: :American journal of respiratory cell and molecular biology 1998
T M Asikainen K O Raivio M Saksela V L Kinnula

Air breathing, especially oxygen therapy, exposes the lung to reactive oxygen species (ROS). Antioxidant enzymes (AOEs) may protect the lung from ROS-mediated injury. Because expression of the key AOEs increases in several animal species during gestation, we investigated (1) the messenger RNA (mRNA) and activity levels of the key AOEs manganese and copper-zinc superoxide dismutases (MnSOD and C...

Journal: :Hypertension 2005
Sean P Didion Dale A Kinzenbaw Frank M Faraci

The goal of the present study was to test the hypothesis that the CuZn isoform of superoxide dismutase (CuZnSOD) protects against angiotensin II (Ang II)-induced endothelial dysfunction. Vascular responses of carotid arteries from control, CuZnSOD-deficient (CuZnSOD(+/-)), and CuZnSOD transgenic mice were examined in vitro after overnight incubation with either vehicle or Ang II (1 or 10 nmol/L...

2011
Jessika Groleau Sylvie Dussault Julie Turgeon Paola Haddad Alain Rivard

OBJECTIVE Aging is associated with increased oxidative stress levels and impaired neovascularization following ischemia. CuZnSOD has an important role to limit oxidative stress in the vasculature. Here we investigated the role of CuZnSOD for the modulation of ischemia-induced neovascularisation during aging. METHODS AND RESULTS Hindlimb ischemia was surgically induced in young (2- month-old) ...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2010
Jessika Groleau Sylvie Dussault Paola Haddad Julie Turgeon Catherine Ménard John S Chan Alain Rivard

OBJECTIVE To investigate the effect of oxidative stress on ischemia-induced neovascularization in copper-zinc (CuZn) superoxide dismutase (SOD)-deficient mice. METHODS AND RESULTS In the vascular wall, CuZnSOD is essential for protecting against excessive oxidative stress and maintaining endothelial function. However, its specific role for the development of new vessels in response to ischemi...

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