background: the effect of several probiotics on diseases of the gastrointestinal tract, including gastric ulcers is well reported. however, there are limited numbers of studies assessing the impact of bacillus subtilis (b. subtilis) probiotic on skin wound healing. m aterials and methods: fifty male rats were assigned to 3 different groups randomly. a 1.5 cm longitudinal full thickness incision...

background: cutaneous leishmaniasis (cl) is a parasitic disease in most parts of iran, especially in the isfahan province. the most common form of cl is a self-healing lesion but in rare situations, infection might develop to non-healing forms. clinical symptoms and treatment process might be influenced by several agents such as host immune response and parasite strains. in this study, the isol...

background and objective: angiogenesis is a complex program of several steps and it is tightly regulated by pro- and anti-angiogenic factors. angiogenesis is one of the key elements in cutaneous wound healing and skin cancers. estrogen seems to have positive modulating effect on cutaneous wound healing and this effect may be explained by its angiogenic properties. this study aims to investigate...

accelerating wound healing is now considered as a principle clinical treatment and increasing the quality and speed of healing which has always been emphasized by the scientists. propolis and honey are natural bee products with wide range of biological and medicinal properties. this study was aimed to determine the synergistic effect of honey and propolis in wound healing of rat skin. a total o...

The skin is densely innervated with an intricate network of cutaneous nerves, neuromediators and specific receptors which influence a variety of physiological and disease processes. There is emerging evidence that cutaneous innervation may play an important role in mediating wound healing. This review aims to comprehensively examine the evidence that signifies the role of innervation during the...

  Background and Objective: Angiogenesis is a complex program of several steps and it is tightly regulated by pro- and anti-angiogenic factors. Angiogenesis is one of the key elements in cutaneous wound healing and skin cancers. Estrogen seems to have positive modulating effect on cutaneous wound healing and this effect may be explained by its angiogenic properties. This study aims to investig...

BACKGROUND Kruppel-like factor KLF4 is a transcription factor critical for the establishment of the barrier function of the skin. Its function in stem cell biology has been recently recognized. Previous studies have revealed that hair follicle stem cells contribute to cutaneous wound healing. However, expression of KLF4 in hair follicle stem cells and the importance of such expression in cutane...

BACKGROUND Nitric oxide (NO) deficiency contributes to diabetic wound healing impairment. The present study tested the hypothesis that increased cutaneous superoxide (O2-) levels in type 1 diabetic mice cause NO deficiency and delayed wound healing. METHODS AND RESULTS Wound healing was markedly delayed in streptozotocin-induced type 1 diabetic mice compared with the normal controls. There we...