نتایج جستجو برای: ctgf

تعداد نتایج: 1816  

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Background: The Connective Tissue Growth Factor (CTGF) gene encoding an extracellular matrix (ECM)-associated protein and as a member of the CCN family of proteins plays a major role in fibrosis, inflammation and connective tissue remodeling in a variety of diseases including cancer. The CCN proteins are multifunctional and are involved in cell proliferation, adhesion and cell development durin...

2013
Leighton R. James Catherine Le Heather Doherty Hyung-Suk Kim Nobuyo Maeda

Connective tissue growth factor (CTGF) is an important mediator of fibrosis; emerging evidence link changes in plasma and urinary CTGF levels to diabetic kidney disease. To further ascertain the role of CTGF in responses to high glucose, we assessed the consequence of 4 months of streptozotocin-induced diabetes in wild type (+/+) and CTGF heterozygous (+/-) mice. Subsequently, we studied the in...

2017
Naohiro Toda Kiyoshi Mori Masato Kasahara Akira Ishii Kenichi Koga Shoko Ohno Keita P. Mori Yukiko Kato Keisuke Osaki Takashige Kuwabara Katsutoshi Kojima Daisuke Taura Masakatsu Sone Taiji Matsusaka Kazuwa Nakao Masashi Mukoyama Motoko Yanagita Hideki Yokoi

Connective tissue growth factor (CTGF) coordinates the signaling of growth factors and promotes fibrosis. Neonatal death of systemic CTGF knockout (KO) mice has hampered analysis of CTGF in adult renal diseases. We established 3 types of CTGF conditional KO (cKO) mice to investigate a role and source of CTGF in anti-glomerular basement membrane (GBM) glomerulonephritis. Tamoxifen-inducible syst...

Journal: :American journal of physiology. Renal physiology 2010
Karin G Gerritsen Hilde P Peters Tri Q Nguyen Maarten P Koeners Jack F Wetzels Jaap A Joles Erik I Christensen Pierre J Verroust Dongxia Li Noelynn Oliver Leon Xu Robbert J Kok Roel Goldschmeding

Connective tissue growth factor (CTGF) plays a key role in renal fibrosis. Urinary CTGF is elevated in various renal diseases and may have biomarker potential. However, it is unknown which processes contribute to elevated urinary CTGF levels. Thus far, urinary CTGF was considered to reflect renal expression. We investigated how tubular dysfunction affects urinary CTGF levels. To study this, we ...

Journal: :Investigative ophthalmology & visual science 2003
Timothy D Blalock Matthew R Duncan Juan C Varela Michael H Goldstein Sonal S Tuli Gary R Grotendorst Gregory S Schultz

PURPOSE Connective tissue growth factor (CTGF) has been linked to fibrosis in several tissues. In this study, the interactions between CTGF and transforming growth factor (TGF)-beta were assessed in human corneal fibroblasts, and the levels and location of CTGF protein and mRNA were measured during healing of excimer laser ablation wounds in rat corneas. METHODS Human corneal fibroblasts were...

2010
Heather E. Doherty Hyung-Suk Kim Sylvia Hiller Kathleen K. Sulik Nobuyo Maeda

Connective tissue growth factor (CTGF) is a signaling molecule that primarily functions in extracellular matrix maintenance and repair. Increased Ctgf expression is associated with fibrosis in chronic organ injury. Studying the role of CTGF in fibrotic disease in vivo, however, has been hampered by perinatal lethality of the Ctgf null mice as well as the limited scope of previous mouse models o...

2014
Hsiao-Chi Tsai Hong-Lin Su Chun-Yin Huang Yi-Chin Fong Chin-Jung Hsu Chih-Hsin Tang

Osteosarcoma, the most common primary malignant bone tumor, shows potent capacity for local invasion and distant metastasis. Connective tissue growth factor (CTGF/CCN2), a secreted protein, binds to integrins, modulates invasive behavior of certain human cancer cells. Effect of CTGF in metastasis of human osteosarcoma is unknown. We found overexpression of CTGF increasing matrix metalloproteina...

Journal: :British journal of haematology 2007
Shoso Munemasa Akira Sakai Yoshiaki Kuroda Yoshiko Okikawa Yuta Katayama Hideki Asaoku Tadahiko Kubo Yoshitaka Miyakawa Masahiro Serikawa Tamito Sasaki Akiro Kimura

Bone disease (BD) in multiple myeloma (MM) is because of the activation of osteoclasts and impairment of osteoblast differentiation. Connective tissue growth factor (CTGF) is known to participate in the differentiation of mesenchymal stem cells to committed osteoprogenitor cells. We analysed the concentration of circulating CTGF in 35 MM patients and 22 malignant lymphoma (ML) patients and 14 n...

Journal: :Investigative ophthalmology & visual science 2012
Timothy D Blalock Daniel J Gibson Matthew R Duncan Sonal S Tuli Gary R Grotendorst Gregory S Schultz

PURPOSE To biochemically characterize the receptor for connective tissue growth factor (CTGF) of human corneal fibroblasts (HCF). METHODS Radiolabeled recombinant human CTGF was used to determine the specificity and time course of binding to low-passage cultures of HCF. The affinity and number of receptors present were calculated by Scatchard and best-fit analyses. In vitro immunoprecipitatio...

Journal: :Circulation 2003
Mónica Rupérez Oscar Lorenzo Luis Miguel Blanco-Colio Vanesa Esteban Jesús Egido Marta Ruiz-Ortega

BACKGROUND Angiotensin II (Ang II) participates in the development of fibrosis during vascular damage. Connective tissue growth factor (CTGF) is a novel fibrotic mediator. However, the potential link between CTGF and Ang II has not been investigated. METHODS AND RESULTS In vivo Ang II effects were studied by systemic infusion into normal rats to evaluate CTGF and extracellular matrix protein ...

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