BACKGROUND AND PURPOSE Cerebral sinovenous thrombosis (CSVT) is increasingly encountered in children, including neonates. The purpose of this study was to assess the frequency and topographic distribution of parenchymal brain lesions associated with CSVT in children and to compare these with the known anatomic venous drainage pathways. MATERIALS AND METHODS Brain CT/CT venograms and/or MR ima...

BACKGROUND The clinical course of cerebral sinus-venous thrombosis (CSVT) is largely unknown because prospective studies with a long follow-up and with the goal to assess thrombosis recurrence rate and predisposing factors for recurrence are lacking. METHODS AND RESULTS One hundred forty-five patients with a first CSVT were followed up for a median of 6 years after discontinuation of anticoag...

The etiology and pathophysiology of cerebral sinus venous thrombosis (CSVT) in the paediatric population is still poorly understood, and the role of thrombophilic risk factors remains to be elucidated. In our multi-center case-controlled study we studied 46 patients with CSVT diagnosed from April 1996 to December 2003, consecutively referred for thrombophilia work-up. The results of thrombophil...

Nephrotic syndrome (NS) is a renal disorder characterized by heavy proteinuria, hypoalbuninemia, edema and hypercholesterolemia. Nephrotic syndrome in children is known to be associated with an hypercoagulable state and thromboembolic complications. However cerebral sinovenous thrombosis (CSVT) is very rare. Here we report a seven-year-old child with steroid-dependent idopathic nephrotic syndro...

Cerebral Venous Sinus (sinovenous) increasingly recognized and diagnosed in pediatric patients. The etiology and pathophisiology has not yet been completely clarified, and unlike adults with CSVT, management in children and neonates remains controversial. However, morbidit continued need for high-quality studies within this field. The following review will highlight aspects of CSVT in the medit...

Evidence-Basis for Anticoagulants for Cerebral Sinus Venous Thrombosis? To the Editor: The recent case of cerebral sinus venous thrombosis (CSVT) in the US Secretary of State Hillary Clinton brought my attention to articles that lay out the evidence-basis for the use of full dose heparin and oral anticoagulant drugs for CSVT. Unfortunately, articles published in Stroke by investigators from the...

Cerebral Venous Sinus (sinovenous) Thrombosis (CSVT) is a serious and rare disorder, increasingly recognized and diagnosed in pediatric patients. The etiology and pathophisiology has not yet been completely clarified, and unlike adults with CSVT, management in children and neonates remains controversial. However, morbidity and mortality are significant, highlighting the continued need for high-...

BACKGROUND Increasing availability of neuroimaging has facilitated the diagnosis of cerebral sinus venous thrombosis(CSVT). However, CSVT may also present with unspecific or atypical symptoms, resulting in diagnostic delay.Single reports suggested otologic symptoms as such pitfalls. OBJECTIVE To screen patients with CSVT for otologic symptoms. DESIGN Ten-year retrospective case series. SE...

Neonatal cerebral sinovenous thrombosis (CSVT) is a rare disease with severe neu­ rological sequelae. Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the folate cycle, and mutations in MTHFR are associated with vascular diseases. Here, we report the case of a newborn with MTHFR mutation­associated CSVT. Analysis of MTHFR in the patient detected heterozygous C677T (677CT) and A129...

Previous studies have indicated a male predominance in pediatric stroke. To elucidate this gender disparity, total testosterone concentration was measured in children with arterial ischemic stroke (AIS; n = 72), children with cerebral sinovenous thrombosis (CSVT; n = 52), and 109 healthy controls. Testosterone levels above the 90th percentile for age and gender were documented in 10 children wi...