نتایج جستجو برای: csf1

تعداد نتایج: 305  

Journal: :Gastroenterology 2015
Benjamin M Stutchfield Daniel J Antoine Alison C Mackinnon Deborah J Gow Calum C Bain Catherine A Hawley Michael J Hughes Benjamin Francis Davina Wojtacha Tak Y Man James W Dear Luke R Devey Alan M Mowat Jeffrey W Pollard B Kevin Park Stephen J Jenkins Kenneth J Simpson David A Hume Stephen J Wigmore Stuart J Forbes

BACKGROUND & AIMS Liver regeneration requires functional liver macrophages, which provide an immune barrier that is compromised after liver injury. The numbers of liver macrophages are controlled by macrophage colony-stimulating factor (CSF1). We examined the prognostic significance of the serum level of CSF1 in patients with acute liver injury and studied its effects in mice. METHODS We meas...

2014
IOANNIS PANAGOPOULOS PETTER BRANDAL LUDMILA GORUNOVA BODIL BJERKEHAGEN SVERRE HEIM

RNA-sequencing was performed on three tenosynovial giant cell tumors (TSGCT) in an attempt to elicit more information on the mechanisms of CSF1 expression in this tumor type. A novel CSF1-S100A10 fusion gene was found in a TSGCT that carried the translocation t(1;1)(q21;p11) as the sole karyotypic abnormality. In this fusion gene, the part of CSF1 coding for the CSF1 protein (exons 1-8 in seque...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2009
Andrew H Beck Inigo Espinosa Badreddin Edris Rui Li Kelli Montgomery Shirley Zhu Sushama Varma Robert J Marinelli Matt van de Rijn Robert B West

PURPOSE Macrophages play an important role in breast carcinogenesis. The pathways that mediate the macrophage contribution to breast cancer and the heterogeneity that exists within macrophages are incompletely understood. Macrophage colony-stimulating factor 1 (CSF1) is the primary regulator of tissue macrophages. The purpose of this study was to define a novel CSF1 response signature and to ev...

Journal: :Endocrine-related cancer 2013
Seyedhossein Aharinejad Mohamed Salama Patrick Paulus Karin Zins Andreas Berger Christian F Singer

Colony-stimulating factor 1 (CSF1) is a key regulator of mammary gland development, and a modulator of tissue macrophages. Expression of the CSF1 receptor gene C-FMS (CSF1R) is strongly associated with poor outcome in breast cancer and results in tumor cell invasiveness and pro-metastatic behavior in vitro. However, CSF1's role as a predictive factor in breast cancer remains unclear. We have pr...

2014
Mary A. Forget Jeffrey L. Voorhees Sara L. Cole Duaa Dakhlallah Ivory L. Patterson Amy C. Gross Leni Moldovan Xiaokui Mo Randall Evans Clay B. Marsh Tim D. Eubank

Reports demonstrate the role of M-CSF (CSF1) in tumor progression in mouse models as well as the prognostic value of macrophage numbers in breast cancer patients. Recently, a subset of CD14+ monocytes expressing the Tie2 receptor, once thought to be predominantly expressed on endothelial cells, has been characterized. We hypothesized that increased levels of CSF1 in breast tumors can regulate d...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2006
Robert B West Brian P Rubin Melinda A Miller Subbaya Subramanian Gulsah Kaygusuz Kelli Montgomery Shirley Zhu Robert J Marinelli Alessandro De Luca Erinn Downs-Kelly John R Goldblum Christopher L Corless Patrick O Brown C Blake Gilks Torsten O Nielsen David Huntsman Matt van de Rijn

Tenosynovial giant-cell tumor (TGCT) and pigmented villonodular synovitis (PVNS) are related conditions with features of both reactive inflammatory disorders and clonal neoplastic proliferations. Chromosomal translocations involving chromosome 1p13 have been reported in both TGCT and PVNS. We confirm that translocations involving 1p13 are present in a majority of cases of TGCT and PVNS and show...

2014
Deborah J Gow Kristin A Sauter Clare Pridans Lindsey Moffat Anuj Sehgal Ben M Stutchfield Sobia Raza Philippa M Beard Yi Ting Tsai Graeme Bainbridge Pamela L Boner Greg Fici David Garcia-Tapia Roger A Martin Theodore Oliphant John A Shelly Raksha Tiwari Thomas L Wilson Lee B Smith Neil A Mabbott David A Hume

We have produced an Fc conjugate of colony-stimulating factor (CSF) 1 with an improved circulating half-life. CSF1-Fc retained its macrophage growth-promoting activity, and did not induce proinflammatory cytokines in vitro. Treatment with CSF1-Fc did not produce adverse effects in mice or pigs. The impact of CSF1-Fc was examined using the Csf1r-enhanced green fluorescent protein (EGFP) reporter...

2018
Catherine A Hawley Rocio Rojo Anna Raper Kristin A Sauter Zofia M Lisowski Kathleen Grabert Calum C Bain Gemma M Davis Pieter A Louwe Michael C Ostrowski David A Hume Clare Pridans Stephen J Jenkins

CSF1 is the primary growth factor controlling macrophage numbers, but whether expression of the CSF1 receptor differs between discrete populations of mononuclear phagocytes remains unclear. We have generated a Csf1r-mApple transgenic fluorescent reporter mouse that, in combination with lineage tracing, Alexa Fluor 647-labeled CSF1-Fc and CSF1, and a modified ΔCsf1-enhanced cyan fluorescent prot...

Journal: :Toxin Reviews 2021

Porthesia scintillans, a serious pest threat to major crops. Here, we evaluated the toxicity of Caulerpa scalpelliformis fractions (CSF1, CSF2, and CSF3) against P. scintillans. Fraction CSF1 attra...

Journal: :Cancer research 2016
Ishani De Megan D Steffen Paul A Clark Clayton J Patros Emily Sokn Stephanie M Bishop Suzanne Litscher Vilena I Maklakova John S Kuo Fausto J Rodriguez Lara S Collier

Current therapies for high-grade gliomas extend survival only modestly. The glioma microenvironment, including glioma-associated microglia/macrophages (GAM), is a potential therapeutic target. The microglia/macrophage cytokine CSF1 and its receptor CSF1R are overexpressed in human high-grade gliomas. To determine whether the other known CSF1R ligand IL34 is expressed in gliomas, we examined exp...

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