Aim: Comparative immunohistochemical study of expression α A Crystallin in non-cataract lenses and age-related cataract humans. Methodology: This was an observational cross sectional study. There are two groups this Group comprised 121 senile degenerative from diagnosed patients. B included 10 patients who underwent surgeries for enucleation due to trauma retinoblastoma. Lenses were fixed 10% B...

Timolol is a non-selective beta-adrenergic receptor antagonist administered for treating glaucoma, heart attacks and hypertension. In the present study, we set out to determine whether or not timolol can provoke cataract formation, thus the influence of timolol on the amyloid-type aggregation of crystallin was investigated. We then provided experimental evidence of crystallin aggregation and it...

The eye of a cephalopod is well-known example convergent evolution and resembles the vertebrate eye. Although cephalopods vertebrates exhibit similar form function, they differ in visual origin structure. common long-arm octopus ( Octopus minor ) good model system evolutionary developmental studies due to its highly centralized nervous system, shorter life cycle, specific camera-type eyes that ...

Timolol is a non-selective beta-adrenergic receptor antagonist administered for treating glaucoma, heart attacks and hypertension. In the present study, we set out to determine whether or not timolol can provoke cataract formation, thus the influence of timolol on the amyloid-type aggregation of crystallin was investigated. We then provided experimental evidence of crystallin aggregation and it...

recently, the use of stem cells has expanded into numerous areas including cell therapy. in this study, we investigated the differentiation capacity of human wharton’s jelly stem cells (hwjscs) into lens fiber cells. morphological changes and expressions of four crystallin genes (αa, αb, βb1 and βb3) were studied. the bovine vitreous body has been shown to induce expression of crystallin genes ...

PURPOSE Previous studies have shown that alpha-crystallin, a major lens protein, acts as a chaperone preventing the thermal denaturation of other lens crystallins. However, there has not been an examination of the alpha-crystallin chaperone ability with respect to the types of insult thought to cause human cataract. Therefore, an examination of the chaperone potential of alpha-crystallin under ...

timolol is a non-selective beta-adrenergic receptor antagonist administered for treating glaucoma, heart attacks and hypertension. in the present study, we set out to determine whether or not timolol can provoke cataract formation, thus the influence of timolol on the amyloid-type aggregation of crystallin was investigated. we then provided experimental evidence of crystallin aggregation and it...

The mechanism of aggregation and insolubilization of lens proteins was examined based on the kinetics of crystallin-crystallin interaction determined by the surface plasmon resonance method on a BlAcore system. Lens proteins are composed mainly of three types crystallins, alpha-, beta-, and gamma-crystallin. The present study indicated that alpha-crystallin shows marked self-interaction. Furthe...