Crystallization plays an important role in separation and purification of the antibiotics. And it is also an indispensable step in preparation of pharmaceuticals with biological activities and specific crystal form. As the last step in purification, crystallization determines the puri‐ ty, crystal habit, granularity and its distribution as well as pharmacologic effect, biologic ac‐ tivity and p...

The chloride intracellular channel (CLIC) family of proteins are unusual in that they can exist in either an integral membrane-channel form or a soluble form. Here, the expression, purification, crystallization and preliminary diffraction analysis of CLIC2, one of the least-studied members of this family, are reported. Human CLIC2 was crystallized in two different forms, both in the presence of...

PICOLON (Pure Inorganic Crystal Observatory for LOw-energy Neutr(al)ino) aims to search cosmic dark matter by high purity NaI(Tl) scintillator. We developed extremely pure crystal hybrid purification method. The recent result of $^{210}$Pb in our is less than 5.7 $\mu$Bq/kg. will report the test experiment low-background measurement at Kamioka Underground Laboratory. sensitivity annual modulati...

A method is described for the large-scale purification of the Bacillus thuringiensis protein crystal by zonal gradient centrifugation. NaBr gradients are employed in a Beckman J21-B centrifuge equipped with a JCF-Z rotor.

We have demonstrated a simple and efficient route for the synthesis of a novel imine based tridentate ligand and its Pd-complex to investigate the C-C cross-coupling reactions, that involve column chromatography purification in only one step. The catalytic activity of the newly synthesized catalyst was studied for the Suzuki, Sonogashira and, Heck cross-coupling reactions under mild conditions....

G protein-coupled receptors (GPCRs) represent the largest family of transmembrane signaling proteins and are the target of approximately half of all therapeutic agents. Agonist ligands bind their cognate GPCRs stabilizing the active conformation that is competent to bind G proteins, thus initiating a cascade of intracellular signaling events leading to modification of the cell activity. Despite...

With continuous technical improvements at synchrotron facilities, data-collection rates have increased dramatically. This makes it possible to collect diffraction data for hundreds of protein-ligand complexes within a day, provided that a suitable crystal system is at hand. However, developing a suitable crystal system can prove challenging, exceeding the timescale of data collection by several...

High quality Hg2Br2 crystal grown <i>via</i> the physical vapor transport (PVT) process is essential for fabrication of acousto-optic tunable filters (AOTFs) module. The full flow, including powder purification and growth, should be systematically established, but there have been few reports about fully established flow single crystal. In this study, we report on entire process, fro...

purpose: the antigen binding fragments of camelids heavy chain antibodies are comprised in one single domain (vhh). the crystal structure of an isolated vhh indicated that it is a problate particle of 2.5 nm in diameter and ∼4 nm high, and has been referred to as a nanobody. the very close similarity of these molecules to human vhs illustrates the potential application of these novel products ...

Bismuth tungstate (Bi2WO6) has become a research hotspot due to its potential in photocatalytic energy conversion and environmental purification. Nevertheless, the limited light absorption fast recombination of photogenerated carriers hinder further improvement performance Bi2WO6. Herein, we provide systematic review for recent advances on Bi2WO6-based photocatalysts. It starts with crystal str...