despite the role of oral corticosteroids in management of sever asthma, use of these drugs needs careful awareness of its many side effects. there are controversies about the role of methotrexate in lowering the need for corticosteroides in these patients. in this study an attempt has been made to determine methotrexate effects in corticosteroid dependent asthma. six patients were entered in a ...

there are evidences that statins have anti-inflammatory effects beyond their cholesterol lowering properties. the study was conducted to assess the effects of atorvastatin on asthma as an inflammatory disease. patients with moderate to severe asthma were entered this randomized, double blind, crossover clinical trial. the impact of oral atorvastatin (10 mg/day) on the lung function of normolipi...

In recent years, the number of studies using a cluster-randomized design has grown dramatically. In addition, the cluster-randomized crossover design has been touted as a methodological advance that can increase efficiency of cluster-randomized studies in certain situations. While the cluster-randomized crossover trial has become a popular tool, standards of design, analysis, reporting and impl...