نتایج جستجو برای: crb

تعداد نتایج: 935  

Feng-Yin Sun, Ming Ming, Xin-hai Cui, Yong-Toa Xu Zhoa-Long Ma

Wilms tumor (WT) is the most common pediatric malignant primary renal tumor. Carboplatin (CRB), a platinum compound is widely used in the treatment of multiple cancers including ovarian, lung, head and neck, and wilm’s tumor. However lower uptake of CRB in cancer cells and toxicity concerns in healthy cells often limited its clinical outcome. The aim of this study was to investigate the antitum...

Journal: :Journal of cell science 2013
Annalisa Letizia Sara Ricardo Bernard Moussian Nicolás Martín Marta Llimargas

Regulated cell shape changes in epithelial cells, which contribute to most organs and tissues, are at the basis of morphogenesis. Crumbs (Crb) is an essential apical determinant controlling epithelial apicobasal polarity. Here we provide evidence for a novel role of Crb apical localisation and stabilisation in controlling cell shape through apical domain organisation and adherens junction posit...

Journal: :Journal of cell science 2011
Annalisa Letizia Sol Sotillos Sonsoles Campuzano Marta Llimargas

Many epithelial tissues undergo extensive remodelling during morphogenesis. How their epithelial features, such as apicobasal polarity or adhesion, are maintained and remodelled and how adhesion and polarity proteins contribute to morphogenesis are two important questions in development. Here, we approach these issues by investigating the role of the apical determinant protein Crumbs (Crb) duri...

Feng-Yin Sun, Ming Ming, Xin-hai Cui, Yong-Toa Xu Zhoa-Long Ma

Wilms tumor (WT) is the most common pediatric malignant primary renal tumor. Carboplatin (CRB), a platinum compound is widely used in the treatment of multiple cancers including ovarian, lung, head and neck, and wilm’s tumor. However lower uptake of CRB in cancer cells and toxicity concerns in healthy cells often limited its clinical outcome. The aim of this study was to investigate the antitum...

حدادی, فرزان, مجیدیان, سینا,

This paper deals with Direction of Arrival (DOA) Estimation using Uniform linear array (ULA) for the case of more sources than sensors in the array processing. Khatri-Rao subspace approach, introduced for DOA estimation for this, in non-stationary signal model. The technique will be shown to be capable to handle stationary signals, too. Identifiability conditions of this approach are addressed....

Journal: :British Dental Journal 2011

Journal: :Current Biology 2010
Brian S. Robinson Juang Huang Yang Hong Kenneth H. Moberg

BACKGROUND Altered expression of apicobasal polarity factors is associated with cancer in vertebrates and tissue overgrowth in invertebrates, yet the mechanisms by which these factors affect growth-regulatory pathways are not well defined. We have tested the basis of an overgrowth phenotype driven by the Drosophila protein Crumbs (Crb), which nucleates an apical membrane complex that functional...

2015
Kristin M. Sherrard Richard G. Fehon

The transmembrane protein Crumbs (Crb) functions in apical polarity and epithelial integrity. To better understand its role in epithelial morphogenesis, we examined Crb localization and dynamics in the late follicular epithelium of Drosophila. Crb was unexpectedly dynamic during middle-to-late stages of egg chamber development, being lost from the marginal zone (MZ) in stage 9 before abruptly r...

Journal: :EURASIP J. Adv. Sig. Proc. 2007
Zhi Wang Saman S. Abeysekera

We discuss the asymptotic Cramer-Rao bound (CRB) for frequency estimation in the presence of multiplicative noise. To improve numerical stability, covariance matrix tapering is employed when the covariance matrix of the signal is singular at high SNR. It is shown that the periodogram-based CRB is a special case of frequency domain evaluation of the CRB, employing the covariance matrix tapering ...

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