BACKGROUND Ventilator-associated pneumonia is a significant cause of morbidity and mortality and may be influenced by oral health. OBJECTIVE To describe the relationship between ventilator-associated pneumonia and oral health status, changes in oral health status during the first 7 days after intubation, and microbial colonization of the oropharynx and trachea. METHODS A total of 66 patient...

The Clinical Pulmonary Infection Score (CPIS) was developed to serve as a surrogate tool to facilitate the diagnosis of ventilator-associated pneumonia (VAP). The CPIS is calculated on the basis of points assigned for various signs and symptoms of pneumonia (eg, fever and extent of oxygenation impairment). Although some studies suggest that a CPIS >6 may correlate with VAP, most studies indicat...

BACKGROUND There is a need to validate and suggest easy clinical method for diagnosis of ventilator-associated pneumonia (VAP) in developing countries. OBJECTIVES To validate the use of simplified Clinical Pulmonary Infection Score (CPIS) for the diagnosis of VAP. DESIGN Prospective study. SETTING Pediatric intensive care unit of a tertiary care teaching hospital. SUBJECTS 30 children r...

BACKGROUND Ventilator-associated pneumonia is associated with increased morbidity and mortality. OBJECTIVE To examine the effects of mechanical (toothbrushing), pharmacological (topical oral chlorhexidine), and combination (toothbrushing plus chlorhexidine) oral care on the development of ventilator-associated pneumonia in critically ill patients receiving mechanical ventilation. METHODS Cr...

We present a technique to leverage annotator rationale annotations for ventilator assisted pneumonia (VAP) classification. Given an annotated training corpus of 1344 narrative chest X-ray reports, we report results for two supervised classification tasks: Critical Pulmonary Infection Score (CPIS) and the likelihood of Pneumonia (PNA). For both tasks, our training data contain annotator rational...

BACKGROUND Early diagnosis of ventilator-associated pneumonia (VAP) is necessary to reduce morbidity and improve survival of critically ill patients in the ICU. The purpose of the present study is to examine the performance of macroscopic bronchoscopic findings and cytological analysis of bronchoalveolar lavage fluid (BALF) as an early diagnostic tool for VAP, either alone or in combination wit...

The purpose of the study is to compare SOFA Score and CPIS by using close suction prevent VAP. This a quasi-experiment without control group. Close used as an intervention. score CIPS were evaluate assesses respiratory, platelet, liver, neurology, cardiovascular, renal function. scores range from 0 24 if mean ≥ 6 indicates functioning organ worse. evaluates body temperature, leucosis, sputum se...

PURPOSE The objective of this study is to determine the role of quantitative cultures of non-bronchoscopic samples such as blinded bronchial sampling (BBS) and endotracheal aspirates (ETA) in the management of ventilator associated pneumonia (VAP). The study also evaluates the clinical diagnosis of VAP based on the inclusion of Gram stain results of BBS/ETA samples into modified clinical pulmon...

Computational prediction of compound-protein interactions (CPIs) is of great importance for drug design as the first step in in-silico screening. We previously proposed chemical genomics-based virtual screening (CGBVS), which predicts CPIs by using a support vector machine (SVM). However, the CGBVS has problems when training using more than a million datasets of CPIs since SVMs require an expon...

Introduction Ventilator-associated pneumonia (VAP) occurs greater than 48 hours following endotracheal intubation and is a clinical diagnosis with no gold standard diagnostic criterion. The Clinical Pulmonary Infection Score (CPIS) is a tool used to aid diagnosis and comprises a clinical score of 0-12 based on 6 variables: body temperature, leukocyte count, volume and character of tracheal secr...