background: mitral valve prolapse (mvp) is now recognized as the most common cardiovalvular abnormality (cva) in the usa, but there has been much less agreement about other aspects of its epidemiology, diagnosis and clinical features. cva analysis still relies mainly on the visual assessment of echocardiographic imaging and manual measurements by experienced cardiologists. so, automating or sem...

INTRODUCTION Continuing professional development (CPD) with corresponding crediting system is recognized as essential for the laboratory medicine specialists to provide optimal service for the patients. Article presents results of the survey evaluating current CPD crediting practice among members of European Federation of Clinical Chemistry and Laboratory Medicine (EFLM). MATERIALS AND METHOD...

To analyze the function of the xeroderma pigmentosum group A (XPA) protein in strand-specific DNA repair, we examined repair of UV-induced cyclobutane pyrimidine dimer (CPD) in transcribed and non-transcribed strands of the dihydrofolate reductase gene of xeroderma pigmentosum group A (XP-A) cell line (XP12ROSV) which was transfected with various types of mutant XPA cDNA. The transfectant overe...

CPD-N is a cytokine-inducible CPD (carboxypeptidase-D) isoform identified in rat Nb2 T-lymphoma cells. The prototypic CPD (180 kDa) has three CP domains, whereas CPD-N (160 kDa) has an incomplete N-terminal domain I but intact domains II and III. CPD processes polypeptides in the TGN (trans-Golgi network) but the Nb2 CPD-N is nuclear. The present study identified a cryptic exon 1', downstream o...

OBJECTIVES To assess and compare contrast sensitivity function in the previously amblyopic and non-amblyopic "normal" eyes of patients with microtropia and anisometropia who achieved 20/20 visual acuity after occlusion therapy. MATERIALS AND METHODS Contrast sensitivity was tested monocularly on both eyes of 34 successfully treated microtropic and 15 anisometropic subjects (visual acuity 20/2...

Received: January 4, 2016 • Revised: February 12, 2016 • Accepted: February 12, 2016 Corresponding Author: Myung Jin Lee (http://orcid.org/0000-0001-9076-7771) 1384 Nambusunhwan-ro, Geumcheon-gu, Seoul 08547, Korea Tel: +82.10.5259.5795 Fax: +82.2.865.5527 email: [email protected] Korean J Med Educ 2016 Jun; 28(2): 153-156. http://dx.doi.org/10.3946/kjme.2016.27 eISSN: 2005-7288 C The Korean...

Selective serotonin reuptake inhibitors (SSRIs) are the only effective pharmacological treatments for obsessive-compulsive disorder (OCD). Nonetheless, their generally limited efficacy, side-effects, and delayed onset of action require improved medications for this highly prevalent disorder. Preclinical and clinical findings have suggested serotonin2C (5-HT2C) receptors as a potential drug targ...

Modeling non-stationary time-series data for making predictions is a challenging but important task. One of the key issues is to identify long-term changes accurately in time-varying data. Bayesian Online Change Point Detection (BO-CPD) algorithms efficiently detect long-term changes without assuming the Markov property which is vulnerable to local signal noise. We propose a Document based BO-C...

Using Ab Initio Multiple Spawning (AIMS) with a Multi-State Multi-Reference Perturbation theory (MS-MR-CASPT2) treatment of the electronic structure, we have simulated the non-adiabatic excited state dynamics of cyclopentadiene (CPD) and 1,2,3,4-tetramethyl-cyclopentadiene (Me4-CPD) following excitation to S1. It is observed that torsion around the carbon-carbon double bonds is essential in rea...

BACKGROUND The Global Adult Tobacco Survey has 15 key indicators, cigarettes smoked per day (CPD) among daily smokers being one of them. The first wave of GATS in 14 countries indicated that mean CPD use is higher in women than men in India only, which is contrary to the current understanding of tobacco use globally. This study was undertaken to understand the unusual findings for mean CPD use ...