BACKGROUND Concomitant use of coumarines and non-steroidal anti-inflammatory drugs (NSAIDs) may induce bleeding complications, due to the inhibition of both coagulant factors and platelet function. Unlike non-selective NSAIDs, cyclo-oxygenase-2 (COX-2)-selective NSAIDs interfere very little with platelet aggregation. AIM To determine whether COX-2-selective NSAIDs are associated with less ble...

Coumarine (2H-1-benzopyran-2-ones) is benzopyrone class compounds and its derivatives are shown a wide spectrum of biological activity. Particularly, coumarine derivative compounds (novobiocin, coumermycin A1, KU135, and chlorobiocin) have an affinity for binding to the CTD and disrupting Hsp90 dimerization. Consequently, these compounds inhibit proper folding of oncogenic client proteins and c...

A series of new 3-formyl coumarine (2) was synthesized in good yields by replacement of chlorine atom by 2 amines. In addition, 5-chromeno-pyrido[2,3-d]pyrimidine-4-yl derivatives (5,6) was synthesized by cyclocondensation of 6aminouracil, the respective ketones and 3-formyl coumarine (2) in one pot-synthesis. Also 2-S-nucleosides analogous of pyrido[2,3-d]-pyrimidines (12-15) was synthesized b...

The present review covers the recent synthetic amino acid derivatives with chemical transformations to peptide derivatives. The amino acids were used as starting keys for synthesis peptides and pseudopeptides derived from pyridinine, coumarine, imaddizole, pyrazole phthalyl, qunolinine and sulfonamide rings. these biomolecules have diverse biological and pharmacological actions, as antimicrobia...

The first reversible interconversion process between a one-strand polymeric copper(II) complex {[Cu2(L1)2(ClO4)2](ClO4)2}n (1) and a dicopper(II) helicate [Cu2(L1-2H)2] (2), proceeding via a deprotonation-protonation process, can transduce fluorescence and function as a fluorescent switch simply by introducing a one fiftieth equivalent of coumarine 343 anion, a fluorophore.

Aβ-peptide ligands based on a cis-glycofused benzopyran structure have been fluores cently labeled using coumarine derivatives. Among the synthesized compounds, two conserved their binding ability to β-amyloid peptides, as shown by NMR experiments. Moreover, exploiting its fluorescent property, it was demonstrated that one of such compounds was able to cross an in vitro model of blood–brain bar...

Field populations of Triatoma infestans Klug were collected during 2002 from four villages in northern Argentina (El Chorro, La Toma, El Sauzal, and Salvador Mazza), after application of deltamethrin and other pyrethroids was ineffective. High levels of resistance to the pyrethroid insecticides deltamethrin, beta-cypermethrin, beta-cyfluthrin, and lambda-cyhalothrin were detected in all of the ...

A theoretical description of micellar dye solutions containing donors and acceptors is developed. It is proved experimentally that the luminescent characteristics of Water-Triton X-100 solutions of Coumarine 1 as a donor and Rhodamine 6G as an acceptor are consistent with the proposed theory. It is shown that the probability of energy transfer between dye molecules and the number of detergent m...