UNLABELLED : Diffusion maps are a spectral method for non-linear dimension reduction and have recently been adapted for the visualization of single-cell expression data. Here we present destiny, an efficient R implementation of the diffusion map algorithm. Our package includes a single-cell specific noise model allowing for missing and censored values. In contrast to previous implementations, w...

To enable the design of large capacity memory structures, novel memory technologies such as non-volatile memory (NVM) and novel fabrication approaches, e.g., 3D stacking and multi-level cell (MLC) design have been explored. The existing modeling tools, however, cover only a few memory technologies, technology nodes and fabrication approaches. We present DESTINY, a tool for modeling 2D/3D memori...

This paper outlines how our highly efficient, power-aware supercomputer called Green Destiny and our open-source parallelization of BLAST called mpiBLAST combine to create a bit of “bioinfomagic.” Green Destiny, featured in The New York Times and winner of a 2003 R&D 100 Award, revolutionized high-performance computing by re-defining performance to focus on issues of efficiency, reliability, an...

a r t i c l e i n f o The current research investigates the role of implicit theories of relationships in modulating aggressive responses to ostracism. Three studies tested whether destiny beliefs (that potential relationships are either fundamentally compatible or not) predispose people to behave aggressively in the wake of ostracism. In Study 1, individual differences in destiny beliefs moder...