A study of the phase and rheological behavior of sucrose hexadecanoate (C16SE)/cosurfactant/water systems in the presence of solubilized oil, using complementary techniques such as dynamic light scattering and small angle X-ray scattering, is presented. Viscoelastic wormlike micellar solutions are found when a nonionic lipophilic cosurfactant is added to C16SE aqueous systems. Contrary to previ...

BACKGROUND AND THE PURPOSE OF THE STUDY Microemulsions are thermodynamically stable, clear dispersions of water, oil, surfactant, and cosurfactant. This study was aimed to develop flurbiprofen microemulsion for enhanced transdermal delivery and investigate the effects of different surfactants and cosurfactants on its delivery and phase behavior. METHOD Various surfactant-cosurfactant mixtures...

The objective of this study was to design and develop o/w microemulsion for transdermal delivery of poorly water soluble acyclovir by aqueous titration method. Oleic acid: castor oil (3:1), tween 80, and ethanol were selected as oily phase, surfactant and cosurfactant respectively. The Pseudoternary phase diagrams were constructed by aqueous titration method. The cosurfactant affect the shape a...

The purpose of this study was to investigate microemulsions as delivery systems for diclofenac sodium (DS). Microemulsion systems were composed of: soybean oil, nonionic surfactants (Brij 58 and Span 80), and different alcohols: ethanol, and 1-buthanol as cosurfactant. The optimum surfactant: cosurfactant (S:CoS) weight ratios and microemulsion areas were detected by the aid of ternary phase di...

Topical microemulsion of capsaicin without surfactant was developed in this study. In these systems, the oil phase was benzyl alcohol, and the cosurfactant was propylene glycol and ethanol. The drop-size of the systems was measured by dynamic light scattering method in order to distinguish true solution from microemulsion. The transdermal performance of the microemulsions was evaluated in vitro...

Garlic bulbs (Allium sativum L.) has an active substance in the form of allicin which is thermolabil, as main antioxidant that can prevent free radicals. Nanoemulsion a particle size 20-500 nm oil and water dispersion system stabilized by combination surfactant cosurfactant. The purpose this study was to obtain best formula from variation VCO concentration 3%, 5%, 8% determine stability nanoemu...

Sodium salicylate containing microemulsions have been formulated, based on the previous phase diagram studies, using a pharmaceutically acceptable surfactant and oil. The effects of formulation variables on the release profile of the drug from microemulsion through intact rat skin were also determined experimentally. In this investigation, two commercially available lecithins (namely Epikuron 2...