three siblings (1 boy, 2 girls) with hypertension and hypokalemia are presented, two with low plasma aldosterone and suppressed renin activity and the eldest with a high renin and aldosterone level due to secondary changes in her kidneys. urinary tetrahydrocortisol (thf) was increased relative to tetrahydrocortisone (the). cortisol ring a reduction constant was also lower than normal. these fin...

Cortisol is the principal glucocorticoid hormone in humans, contributing to homeostatic regulation of basal metabolism and salt and water balance, and modulating the response to stress. Normal adult human adrenal glands secrete around 5—15mg per day of cortisol. Only a small fraction is excreted as free cortisol in urine, saliva or bile. The rest is cleared by several metabolic pathways before ...

background glucose is an essential element in the supply of body’s energy. in diseases such as diabetes, glucose increase is associated with disturbance in metabolism. cortisol is an important hormone in the regulation of glucose metabolism, and human serum albumin (hsa) is one of the most important glucose and cortisol transmitters in blood. interaction between albumin and these ligands could ...

KEY POINTS Fetal nutrient supply is dependent, in part, upon the transport capacity and metabolism of the placenta. The stress hormone, cortisol, alters metabolism in the adult and fetus but it is not known whether cortisol in the pregnant mother affects metabolism of the placenta. In this study, when cortisol concentrations were raised in pregnant sheep by infusion, proportionately more of the...

BACKGROUND Critical illness is often accompanied by hypercortisolemia, which has been attributed to stress-induced activation of the hypothalamic-pituitary-adrenal axis. However, low corticotropin levels have also been reported in critically ill patients, which may be due to reduced cortisol metabolism. METHODS In a total of 158 patients in the intensive care unit and 64 matched controls, we ...

BACKGROUND/AIMS Cortisol plays an important role during pregnancy. It controls maternal glucose metabolism and fetal development. Cortisol metabolism is partially controlled by the 11b-HSD2. This enzyme is expressed in the kidney and human placenta. The activity of the enzyme is partially controlled by functional polymorphisms: the HSD11B2[CA]n microsatellite polymorphism. The impact of this fu...

A major proportion of the metabolites of cortisol in man. have been clearly characterized (1). Current concepts of the metabolism of cortisol in viva emphasize the ability of the liver to transform large quantities of the adrenal hormone per unit time (2-7). To study hepatic and extrahepatic metabolism of cortisol by experimental means not adaptable to man, the dog was used. It is the purpose o...

introduction exercise is associated with an increase in cortisol - the most important hormone in fat metabolism. cortisol levels vary during a day. this study was conducted in view of the lack of any documents on cortisol levels in endurance athletics in iran. methods in a cross-sectional study, 25 male endurance runners age 18-25 years and 25 non-athlete men were selected. the cortisole and tg...