neovascularization of the normally avascular cornea was associated with a notable increase in the expression of the major pro-angiogenic factors, inflammatory cytokines and proteases. the data supporting a causal role for vascular endothelial growth factor (vegf), inflammatory cytokines and matrix metalloproteinase (mmps) are extensive. anti-angiogenic/anti-inflammatory therapy is considered as...

background: to compare the efficacy of subconjunctival administration of bevacizumab and different doses of sunitinib malate in reducing corneal neovascularization (cnv). materials and methods: in this experimental study, central corneal cauterization was created in the right eye of fifty male sprague–dawley rats. on day 1 (1 week after cauterization), rats were randomly assigned into five trea...

Dasa-NLC could significantly inhibit the corneal neovascularization.

introduction: the aim of the present study was to evaluate the effect of photodynamic therapy in the treatment of experimental corneal neovascularization (nv) with benzoporphyrin derivative (bpd). methods: one group was considered as control (n=6 eyes) then, corneal nv was induced in 30 new zealand male rabbits (n=60 eyes) by placing 7.0 silk sutures at midstromal depth approximately1mm from th...

Corneal neovascularization leads to blurred vision, thus in vivo visualization is essential for pathological studies in animal models. Photoacoustic (PA) imaging can delineate microvasculature and hemodynamics noninvasively, which is suitable for investigating corneal neovascularization. In this study, we demonstrate in vivo imaging of corneal neovascularization in the mouse eye by optical-reso...

This review provides a detailed summary of the issues etiology, pathogenesis and molecular mechanisms corneal neovascularization. Signaling molecules involved in process neovasculogenesis, as well their antagonists, antiangiogenic factors, are described. The role signaling proteins VEGF, MMP receptors modern targets therapy is described on basis series clinical studies. potentials gene bioengin...

OBJECTIVE Thalidomide is a potent inhibitor of angiogenesis. We evaluated the effects of Thalidomide on corneal angiogenesis and on tissue survival of grafts in rabbit eyes with pre-existing neovascularization secondary to alkali burn. METHODS Sixteen rabbits received alkali burns to one cornea. One month post-injury, assessments of corneal neovascularization were performed followed by cornea...

AIM To compare the effect of topically administered and subconjunctivally injected bevacizumab on experimental corneal neovascularization in rats for two weeks after treatment. METHODS Twenty-eight Sprague-Dawley rats were divided into four groups of 7 animals. Each corneal center of right eye was cauterized with silver/potassium nitrate for 8s. After corneal burning, bevacizumab (12.5mg/mL) ...

PURPOSE Matrilysin, matrix metalloproteinase (MMP)-7, is upregulated in the corneal epithelium during wound healing after excimer keratectomy wounds. The purpose of this study was to determine the role of matrilysin in maintaining corneal avascularity during wound healing. METHODS Matrilysin-deficient mice (n = 17) and their age-matched wild-type littermates (n = 18) were treated with 193 nm ...

PURPOSE The purpose of the current study was to investigate the effect of topical administration of KH906 on corneal neovascularization (NV). METHODS To induce corneal neovascularization, chemical cauterization of the corneas of the right eyes of forty-eight New Zealand white rabbits was performed by touching the central cornea with an 8-mm-diameter NaOH-soaked Whatman filter paper for 60 s. ...