نتایج جستجو برای: copper sulfateseizurepentylenetetrazole valproic acid

تعداد نتایج: 821568  

Journal: :journal of basic and clinical pathophysiology 2013
mohammad reza palizvan abolfazl jand mohammad reza taherinejad

background and objective: copper is one of the main micronutrients of body which plays a key role as a cofactor in the function of metabolic enzymes. previous studies have shown that copper sulfate () inhibits long-term potentiation (ltp) in slices of hippocampal ca1 region. whereas ltp is involved in learning and epilepsy, it seems that copper effects on ltp could be associated with its effect...

2011
Natalia Lampon J. Carlos Tutor

BACKGROUND Patients treated with valproic acid (VPA) present a high incidence of non-alcoholic fatty liver disease (NAFLD) (around 61%). Several recent studies suggest that low copper stores could be associated with NAFLD, and a significant decrease of copper availability in VPA-treated patients has been described. DESIGN AND METHODS In 101 adult epileptic patients treated with valproic acid ...

 Background and purpose: It is well established that valproic acid (VPA) is teratogenic associated with oxidative stress in humans and in all animal species tested. In this study, considering the chemical composition of catechins, we investigated its protective effect on the survival of PC12 nerve cells exposed to valproic acid. Materials and methods: The protective effects of epicatechin (EC)...

Journal: :iranian journal of medical physics 0
ahmad yarmohamadi biochemistry and metabolic disorders research center, golestan university of medical sciences, gorgan, iran jahanbakhsh asadi biochemistry and metabolic disorders research center, golestan university of medical sciences, gorgan, iran alireza khoshbin khoshnazar biochemistry and biophysics dept of golestan university of medical sciences.faculty of medicine, golestan university of medical sciences.begin of shast colah road.gorgan .iran mohammad mostakhdem hashemi laboratory sciences research center, golestan university of medical sciences, gorgan, iran

introduction h istone deacetylase inhibitors (hdis), as  radiation sensitizing agents, are considered as a novel class of anti-cancer factors, which are studied in various tumor cell-lines. valproic acid (vpa) is an hdi, which is effectively used in the treatment of epilepsy, migraines, and some particular types of depression. in this study, we evaluated the effects of vpa and ionizing radiatio...

Journal: :iranian journal of psychiatry and behavioral sciences 0
victoria omranifard department of psychiatry, research center of psychiatry and behavioral sciences, isfahan, iran afsaneh karbasi amel siamak amanat

objective: although sodium valproate came to the market as an anticonvulsant drug, nowadays it's wildly used in the management of psychiatric disorders. it is used as a mood stabilizer and as an adjunctive agent in treatment of depression and psychosis. there are controversies regarding sodium valproate efficacy in psychosis. although some studies have reported that it is effective in the ...

Journal: :acta medica iranica 0
m.akbari1 f. abolhassani m. azizi a.r. dehpour m.ansari m.a. ahmadi faghih a. hedayatpour

valproic acid is one of the main antiepileptic drugs. there is an increased risk of neural tube defects and axial skeletal malformations among infants born to women who had received valproic acid. there is a hypothesis that one biochemical abnormality underlying the teratogenicity of valproic acid is a drug-induced reduction in maternal plasma zinc .in the present experimental study mated rats ...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه صنعتی خواجه نصیرالدین طوسی - دانشکده علوم 1391

abstract in the present research solution of chalcopyrite in sulfuric acid in hydrometallurgy method using electrochemistry with cyclic voltammetry technique has been investigated. the value of maximum reduction peak current of copper ions represents the measure of solubility. in this research different parameters temperature, potential, potential exert time, chalcopyrite concentration, sulfur...

2014
Evan S. Schwarz Mark Thoelke

Valproic acid is used in the treatment of multiple disorders. Adverse effects from valproic acid include hepatotoxicity, hypotension, metabolic acidosis, and decreased mental status. Valproic acid also causes hyperammonemia. Many physicians assume that this is due to a supratherapeutic valproic acid concentration; when in fact, it can occur with therapeutic valproic acid concentrations. This is...

11, 25 dihydroxy vitamin D3, an active metabolite of vitamin­D3 has been reported to inhibit the growth of number neoplasms such as prostate, breast, colorectal, leukemia and skin cancers. Valproic acid, as a potent histone deacetylase inhibitor, also plays an important role in inhibition of proliferation of tumor cells. However, there are no reports so far on the cooperation between valpro...

Journal: :iranian biomedical journal 0
علیرضا عبدانی پور alireza abdanipour hermann j. schluesener تقی طریحی taki tiraihi

background: the primary phase of traumatic spinal cord injury (sci) starts by a complex local inflammatory reaction such as secretion of pro-inflammatory cytokines from microglia and injured cells that substantially contribute to exacerbating pathogenic events in secondary phase. valproic acid (vpa) is a histone deacetylase inhibitor. acetylation of histones is critical to cellular inflammatory...

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