Although cisplatin is one of the most effective cancer drugs which is widely used in the treatment of various neoplasms, its side effects, especially vomiting may limit its use. It has been demonstrated that cytotoxic drugs lead to a sudden release of serotonin (5-HT). The following study was performed to determine the possible interactions of cisplatin with 5-HT receptors. In this study, the...

angiotensin ii is a major endocrine hormone that affects directly both vascular smooth muscle and endothelial cells. since vascular reactivity to angiotensin ii changes in more physiological and pathophysiological conditions, the present study was performed to investigate the effect of intraperitoneal administration of angiotensin-converting enzyme inhibitor and captopril (30 and 50 mg kg-1, on...

Background and Aims: Diabetes mellitus is accompanied with higher incidence of cardiovascular disorders. There is some evidence on antidiabetic potential of silymarin. In this study the effect of chronic administration of silymarin on contractile-relaxation response of thoracic aorta of diabetic rats was investigated. Methods: In this experimental study, male Wistar rats were divided into 5 gro...

Artemisia species, growing in almost all the northern hemisphere, is used in folk medicine of some countries as a remedy for hypertension. Since some cardiovascular disorders including hypertension are accompanied with altered responsiveness of vascular alpha-adrenergic receptors, the effect of aqueous Artemisia annua extract (100 and 200 mg kg-1) on a1-adrenoceptor agonist-induced contraction ...

Angiotensin II is a major endocrine hormone that affects directly both vascular smooth muscle and endothelial cells. Since vascular reactivity to angiotensin II changes in more physiological and pathophysiological conditions, the present study was performed to investigate the effect of intraperitoneal administration of angiotensin-converting enzyme inhibitor and captopril (30 and 50 mg kg-1, on...

Considering the anti-diabetic potential of Trigonella foenum-graecum (TFG) and its beneficial effect on aortic reactivity of diabetic rats, this study was conducted to evaluate the effect of its alcoholic seed extract on aortic reactivity and also figure out mechanisms including the role of adrenergic and angiotensinergic systems in streptozotocin-diabetic rats. Male Wistar rats were divided in...

Considering the anti-diabetic potential of Trigonella foenum-graecum (TFG) and its beneficial effect on aortic reactivity of diabetic rats, this study was conducted to evaluate the effect of its alcoholic seed extract on aortic reactivity and also figure out mechanisms including the role of adrenergic and angiotensinergic systems in streptozotocin-diabetic rats. Male Wistar rats were divided in...