نتایج جستجو برای: connexins

تعداد نتایج: 3407  

Journal: :Frontiers in Molecular Neuroscience 2021

Astrocytes play a crucial role in the maintenance of normal functions Central Nervous System (CNS). During pathogenesis neurodegenerative diseases, astrocytes undergo morphological and functional remodeling, process called reactive astrogliosis, response to insults CNS. One key aspects is change expression function connexins. Connexins are channel proteins that highly expressed astrocytes, form...

Journal: :basic and clinical neuroscience 0
mohammad abbasian mohammad sayyah vahab babapour reza mahdian

introduction: gap junctions are intercellular membrane channels that provide direct cytoplasmic continuity between adjacent cells. this communication can be affected by changes in expression of gap junctional subunits called connexins (cx). changes in the expression and function of connexins are associated with number of brain neurodegenerative diseases. neuroinflammation is a hallmark of vario...

Journal: :The Journal of Cell Biology 1994
M M Falk N M Kumar N B Gilula

Connexins, the proteins that form gap junction channels, are polytopic plasma membrane (PM) proteins that traverse the plasma membrane bilayer four times. The insertion of five different connexins into the membrane of the ER was studied by synthesizing connexins in translation-competent cell lysates supplemented with pancreatic ER-derived microsomes, and by expressing connexins in vivo in sever...

2013
Merlijn J. Meens Anna Pfenniger Brenda R. Kwak Mario Delmar Leon H. Charney

Connexins form a family of transmembrane proteins that consists of 20 members in humans and 21 members in mice. Six connexins assemble into a connexon that can function as a hemichannel or connexon that can dock to a connexon expressed by a neighbouring cell, thereby forming a gap junction channel. Such intercellular channels synchronize responses in multicellular organisms through direct excha...

Journal: :Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2000
E C Beyer J Gemel K H Seul D M Larson K Banach P R Brink

Intercellular communication may be regulated by the differential expression of subunit gap junction proteins (connexins) which form channels with differing gating and permeability properties. Endothelial cells express three different connexins (connexin37, connexin40, and connexin43) in vivo. To study the differential regulation of expression and synthesis of connexin37 and connexin43, we used ...

Journal: :Cardiovascular research 2013
Merlijn J Meens Anna Pfenniger Brenda R Kwak Mario Delmar

Connexins form a family of transmembrane proteins that consists of 20 members in humans and 21 members in mice. Six connexins assemble into a connexon that can function as a hemichannel or connexon that can dock to a connexon expressed by a neighbouring cell, thereby forming a gap junction channel. Such intercellular channels synchronize responses in multicellular organisms through direct excha...

Mohammad Abbasian, Mohammad Sayyah, Reza Mahdian, Vahab Babapour,

Introduction: Gap junctions are intercellular membrane channels that provide direct cytoplasmic continuity between adjacent cells. This communication can be affected by changes in expression of gap junctional subunits called Connexins (Cx). Changes in the expression and function of connexins are associated with number of brain neurodegenerative diseases. Neuroinflammation is a hallmark of vario...

Journal: :Biochimica et Biophysica Acta (BBA) - Biomembranes 2004

2016
Debarshi Banerjee

Gap junctions are cell-to-cell junctions that are located in the basolateral surface of two adjoining cells. A gap junction channel is composed of a family of proteins called connexins. Gap junction channels maintain intercellular communication between two cells through the exchange of ions, small metabolites, and electrical signals. Gap junction channels or connexins are widespread in terms of...

Journal: :Frontiers in Cellular Neuroscience 2021

Electrical synaptic transmission is an essential form of interneuronal communication which mediated by gap junctions that permit ion flow. Three gene families (connexins, innexins, and pannexins) have evolved to junctional channels. Each channel formed the docking hemichannel one cell with corresponding adjacent cell. To date, there has been a lack study models describe this structure in detail...

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