The first actinide triple helices, including two supramolecular conformational isomers of uranium(VI), have been synthesized with the aid of a flexible V-shaped ligand and a rigid aromatic base. The isomers exhibit an intriguing pH-dependent structural evolution and a kinetically-controlled transformation via a novel conformational rearrangement of the organic base.

We examine a simple model of rotaxane structure, with 3 asymmetric rings interacting via repulsive power-law forces. This interlocked molecule exhibits conformational isomerisation which is different from that of molecules whose connectedness is through covalent bonds. The rings are free to translate along and rotate around the axle, and hence weak interaction forces between the rings can lead ...

Unprecedented non-interconvertable conformational isomers derived from cyclic amide ligands in a paddlewheel dimetallic framework are reported.

Thrombopoietin receptor agonist humanized VB22B single-chain diabody (hVB22B (scFv)(2)) was found to be expressed as a mixture of two conformational isomers, a single-chain diabody form and a bivalent scFv form, which had different V(H)/V(L) (variable region of the heavy chain/light chain) association patterns. The single-chain diabody form showed significantly higher biological activity than t...

Stilbene (1,2-diphenylethylene) has shown an intriguing isomerisation behavior and may serve as a model system for ‘‘molecular switches’’ incorporating a C=C double bond. To evaluate the possible use of such molecules as molecular switches on semiconductor surfaces, the adsorption of cisand trans-stilbene on Si(100) has been investigated. Identification of both isomers is achieved by difference...