[this article has been retracted for duplicate publication] background: the pathological classification of cryptogenic fibrosing alveolitis has been a matter of debate and controversy for histopathologists. objective: to identify and specify the glycotypes of capillary endothelial cells in usual interstitial pneumonia (uip) compared to those found in normal tissue. methods: sections of formalin...

Multivalent interactions between carbohydrate-encapsulated gold nanoparticles and Con A are found with high affinity and specificity.

The induction by anti-immunoglobulin of patch and cap formation on mouse lymphocytes was inhibited by the addition of concanavalin A. This effect was reversed by alpha-methyl-D-mannoside, a competitive inhibitor of the binding of concanavalin A. Concanavalin A prevented both patch and cap formation, in contrast to the metabolic inhibitor NaN(3), which prevented only cap formation. This suggests...

A new class of sulfurated, semi-rigid, radial and low-valent glycosylated asterisk ligands with potential dual function as ligand and probe has some of the highest inhibition potencies of Con A-induced hemagglutination, by using a cross-linking mechanism of Con A which amplifies the enhancement to near nanomolar concentrations with the alpha-d-mannose asterisk.

The advent of high speed, cell analysis systems (1-5) for rapid measurement of physical and biochemical properties in single cells has provided new and useful techniques for performing a wide variety of biological experiments . Such systems recently have been used in studies related to DNA content per cell as a function of chromosome number (6, 7), effects of chemotherapeutic agents on cell cyc...

Receptor clustering by multivalent ligands can activate signaling pathways. In principle, multivalent ligand features can control clustering and the downstream signals that result, but the influence of ligand structure on these processes is incompletely understood. Using a series of synthetic polymers that vary systematically, we studied the influence of multivalent ligand binding epitope densi...