primary immunodeficiencies constitute a group of highly complex congenital disorders most of which are characterized by a very poor prognosis. allogeneic hematopoietic stem cell transplantation (hsct) has become an established curative treatment approach in many of these disorders, which may be permanently corrected. in this presentation basic and practical aspects of hsct are presented, with a...

introduction bacillus calmette-guérin (bcg) vaccine, a live attenuated mycobacterium bovis strain, is administrated to all newborn infants in endemic regions according to the current world health organization (who) recommendation. case presentation we report a 10-month-boy who was a known case of severe combined immunodeficiency (scid) admitted with multi-focal fusiform painful swelling in his ...

scid disorder is major failure of the immune system, usually genetic. the aim of this study was on mutations detection of rag1, rag2, and il7rg genes in scid cases. mutation detection was performed by pcr sequencing. our results  indicated  that 13  mutations  were found  through  cases which  include 4 mutations in il7r gene (t661i, i138v, t56a, c57w), 7 mutations in rag1 (w896x, w204r, m324v,...

the (bacille calmette-gue´rin) bcg is widely practiced in many countries in pediatric group and is a part of routine vaccination program at birth in ir. iran for prophylaxis against tuberculosis, but its efficacy is a matter of debate in different geographic and ethnic regions. adverse reactions induced by bcg vaccination ranges from bcg adenitis, osteitis, and cold abscess at vaccination site ...

Major histocompatibility complex (MHC) class II deficiency is a primary immunodeficiency disease characterized by abnormality of MHC class II molecules surface expression on peripheral blood lymphocytes and monocytes. Clinical manifestations include extreme susceptibility to viral, bacterial, and fungal infections but the immunodeficiency is not as severe as SCID (severe combined immunodeficien...

Children presenting with disseminated viral infections should be carefully investigated because they almost invariably have an underlying immunodeficiency. A child is reported who had disseminated cytomegalovirus and a novel form of severe combined immunodeficiency with abnormal expression of the common leucocyte antigen, CD45.