In this paper, it has been attempted to evaluate the performance of asphalt overlays which were reinforced with geogrid, modified by sasobit and combination of them on rehabilitation of reflective cracking. The laboratory tests under dynamic loading in bending mode were conducted to investigate reflective cracking retardation compared to reference samples. The results illustrated that in a cert...

in 99 patients (79%) who received ribavirin for HCPS, and 26 (21%) required blood transfusions. Three subjects were withdrawn from the study because of pancreatitis. Although we agree that it can be difficult to obtain larger sample sizes in studies of rare infectious diseases (as evidenced by the low enrollment rate in the study of HCPS by Mertz et al. [1]), one should be clear about the limit...

The use of multiple drugs in a single clinical trial or as a therapeutic strategy has become common, particularly in the treatment of cancer. Because traditional trials are designed to evaluate one agent at a time, the evaluation of therapies in combination requires specialized trial designs. In place of the traditional separate phase I and II trials, we propose using a parallel phase I/II clin...

Co-sleeping has been considered as a dangerous sleeping practice for infants by some parents and pediatricians. However, past research found that co-sleeping in early childhood has a positive influence on both physical and mental development as well as the parent-child relationship, which suggests that co-sleeping may have a positive influence on self-regulation development. This study aims to ...

The article by Savina et al. from the large METASARC database of the French Sarcoma Group (BMC Med 15:78, 2017) provides a wealth of information about the natural history and therapy of patients with metastatic soft tissue sarcomas. The information complements - and in some cases surpasses - that obtained from randomized clinical trials, and should not be overlooked because of its retrospective...