Abstract Introduction: Colorectal cancer is the third most prevalent malignancy with high mortality rate, necessitating markers that predict survival and guide the treatment. Previous studies have examined the immunohistochemical expression of Bcl-2, an apoptotic marker, in colorectal carcinoma, but results have been contradictory. Objectives: To evaluate the histopathological featu...

following failure of systemic chemotherapy, transarterial chemoembolization (tace) is an available method to control unresectable liver metastases from colorectal carcinoma (crc). the aim of present study was to evaluate the efficacy of chemoembolization for inoperable metastatic liver lesions from crc. forty-five crc patients with liver metastases resistant to systemic chemotherapy were enroll...

 Metastatic ovarian cancers occur in 3-8 percent of women undergoing surgical resection of a primary colorectal cancer. In this study we examined the characteristics of women with colorectal cancer for whom synchronous oophorectomy had been performed. In this cross-sectional study, records of patients with colorectal cancer from April 1991 through October 1999 who had undergone surgery for both...

Background & Objective: The current approaches to reduce the risk of colorectal carcinoma are through the detection and removal of the precursor lesion” adenomatous polyps”. The study was conducted to evaluate the immunohistochemical expression of p53 and bcl2 in colorectal adenomas and carcinomas. Patients and Methods: A total of 86 cases, 33 colorectal adenomas, 33 colorect...

Synchronous cancer is referred to two or more histological distinct malignancies diagnosed during the same hospital admission. Globally more than 1 million people get colorectal cancer yearly resulting in about 0.5 million deaths. Vulvar cancer is the fourth most common gynecologic cancer (following the corpus uterine cancer, cancer of ovary and cervix) and comprises only 4 percent of malignanc...

synchronous cancer is referred to two or more histological distinct malignancies diagnosed during the same hospital admission. globally more than 1 million people get colorectal cancer yearly resulting in about 0.5 million deaths. vulvar cancer is the fourth most common gynecologic cancer (following the corpus uterine cancer, cancer of ovary and cervix) and comprises only 4 percent of malignanc...

the basic pathogenic step in the process of tumor growth, invasion and metastasis is tumor-induced angiogenesis. the aim of this study was to evaluate the angiogenesis in colorectal carcinoma by microvascular density (mvd) determination with ihc (immunohistochemistry) method and to determine if and how angiogenesis correlates with clinicopathologic parameters. sixty two archival, paraffin embed...

Background: Activation of the ubiquitin-proteasome pathway in various malignancies, including colorectal cancer, is established. This pathway mediates the degradation of damaged proteins and regulates growth and stress response. The novel human gene, UBE2Q2, with a putative ubiquitin-conjugating enzyme activity, is reported to be overexpressed in some malignancies. We sought to investigate the ...

lymph node dissection is of prime importance for accurate staging of colorectal carcinomas. since a great number of small lymph nodes are missed in the traditional method, several fat clearing solutions have been introduced for easier detection of smaller lymph nodes. in this study we evaluated the efficacy of a new fat clearing solution so-called lymph node revealing solution (lnrs) in colecto...

background: activation of the ubiquitin-proteasome pathway in various malignancies, including colorectal cancer, is established. this pathway mediates the degradation of damaged proteins and regulates growth and stress response. the novel human gene, ube2q2, with a putative ubiquitin-conjugating enzyme activity, is reported to be overexpressed in some malignancies. we sought to investigate the ...