chitosan with excellent biodegradable and biocompatible characteristics has received attention as an oral drug delivery vehicle for controlled-release formulations. in this study an enteric-coated capsule containing theophylline-chitosan beads based on 23 factorial designs was prepared as a colon drug delivery system. the theophylline-chitosan gel beads were formulated by adding the drug-contai...

the main objective of this study was to prepare colon-specific pellets of budesonide, using pectin as film coating. pellet cores of budesonide were prepared by extrusion / spheronization technique. pectin, in different ratios was combined with eudragit rs30d, eudragit ne30d or surelease to produce film coating. the dissolution profiles of pectin coated pellets were investigated in ph of 1.2 (2 ...

a controlled release matrix formulation for mesalamine was designed and developed to achieve a 24 h release profile. using compritol 888 ato (glyceryl behenate) as an inert matrix-forming agent to control the release of mesalamine, formulation granules containing the solid dispersions were investigated. pectin, a polysaccharide, was used as bacterial dependent polymer for colon targeting. the m...

The colon is a site where both local and systemic delivery of drugs can take place. Local delivery allows topical treatment of inflammatory bowel disease. However, treatment can be made effective if the drugs can be targeted directly into the colon, thereby reducing the systemic side effects. This review mainly describes the primary approaches for CDDS (Colon Specific Drug Delivery) namely prod...

Nowadays, various routes of administration have been explored for the effective delivery drug to target site. The oral route is considered be most convenient drugs patients. But it has a serious drawback in conditions where localized colon required. colon-targeted system (CDDS) potential approach systemic and topical treating inflammatory bowel diseases such as ulcerative colitis, Crohn’s disea...

Colon specific drug delivery has gained increased importance not for the treatment of local diseases associated with the colon but also as potential site for systemic delivery of therapeutic proteins and peptides. Colon is a site where both local and systemic delivery of drug can take place. Treatment could be more effective if it is possible for drug to be directly to colon. Systemic side effe...

Oral administration of different dosage forms is the most commonly used method due to flexibility in design of dosage form and high patient acceptance, but the gastrointestinal tract presents several formidable barriers to drug delivery. In oral colon-specific drug delivery system, colon has a large amount of lymphoma tissue (facilitates direct absorption in to the blood), negligible brush boar...

In the current year colonic drug delivery has gained significance for delivery of drug for the treatment of local diseases related with colon and systemic delivery of therapeutic peptides and proteins. Management could be more effective if it is possible for drug to be directly delivered to colon. This article gives an overview on different approaches utilized for colon specific drug delivery.

Although oral delivery has become a widely accepted route of administration of therapeutic drugs, the gastrointestinal tract presents several formidable barriers to drug delivery. Colonic drug delivery has gained valued attention not just for the targeted delivery and effective therapy of local diseases associated with the colon but also for its potential for the delivery of proteins and therap...