Colicins are proteins produced by some strains of Escherichia coli to kill competitors belonging to the same species. Among them, ColM (colicin M) is the only one that blocks the biosynthesis of peptidoglycan, a specific bacterial cell-wall polymer essential for cell integrity. ColM acts in the periplasm by hydrolysing the phosphoester bond of the peptidoglycan lipid intermediate (lipid II). Co...

The authenticated encryption scheme COLM is a third-round candidate in the CAESAR competition. Much like its antecedents COPA, ELmE, and ELmD, COLM consists of two parallelizable encryption layers connected by a linear mixing function. While COPA uses plain XOR mixing, ELmE, ELmD, and COLM use a more involved invertible mixing function. In this work, we investigate the integrity of the COLM str...

Bacteria host an arsenal of antagonism-mediating molecules to combat for ecologic space. Bacteriocins represent a pivotal group of secreted antibacterial peptides and proteins assisting in this fight, mainly eliminating relatives. Colicin M, a model for peptidoglycan-interfering bacteriocins in Gram-negative bacteria, appears to be part of a set of polymorphic toxins equipped with such a cataly...

Poorly-differentiated colorectal cancers (PD-CRC) show high metastatic potential and poor prognosis. However, molecular characteristics of PD-CRC remain unknown to date, particularly in molecular targeting therapy for patients with PD-CRC. In this study, we examined the expression of EGFR, HER2 and HER3 in PD-CRC by immunohistochemical analysis of archived clinical specimens of primary tumors a...

Land surface models (LSMs) are important tools for simulating energy, water and momentum transfer across the land–atmosphere interface. Many LSMs have been developed over the past 50 years, including the Common Land Model (CoLM), a LSM that has primarily been developed and maintained by Chinese researchers. CoLM has been adopted by several Chinese Earth System Models (GCMs) that will participat...

Authenticated encryption schemes are important cryptographic primitives that received extensive attention recently. They can provide both confidentiality and authenticity services, simultaneously. Correlation power analysis (CPA) can be a thread for authenticated ciphers, similar to the any physical implementation of any other cryptographic scheme. In this paper, a three-step CPA attack against...

The aim of antitumor immunotherapy is to induce CTL responses against autologous tumors. Previous work has shown that fusion of human dendritic cells and autologous tumor cells induce CTL responses against autologous tumor cells in vitro. However, in the clinical setting of patients with colorectal carcinoma, a major difficulty is the preparation of sufficient amounts of autologous tumor cells....

Most current land surface models (LSMs) coupled to regional climate models (RCMs) have been implemented at the several tens of kilometer spatial scales. Modeling land surface processes in LSMs at a finer resolution is necessary for improvements in terrestrial water and energy predictions especially for small catchments. This study has therefore assessed the applicability of high-resolution simu...

This thesis will explore the deterministic dynamics of systems of coupled oscillators. In particular, the focus of the thesis will be concerned with the transport properties of these systems. Of interest is how particles work together, cooperatively, to achieve directed transport. For this reason, the strength of the coupling between the particles will serve as the main control parameter. Furth...