Various strategies have been employed to speed tissue regeneration using bioactive molecules. Interestingly, platelet concentrates derived from a patient's own blood have been utilized as a regenerative strategy in recent years. In the present study, a novel liquid platelet formulation prepared without the use of anti-coagulants (injectable-platelet-rich fibrin, i-PRF) was compared to standard ...

Tissue engineering-based therapies rely on the delivery of monolayered fibroblasts on two-dimensional polystyrene-coated and extracellular matrix (ECM) surfaces to regenerate connective tissues. However, this approach may fail to mimic their three-dimensional (3D) native architecture and function. We hypothesize that ECM fibrous proteins, which direct the migration of cells in vivo, may attach ...

the alteration of cytokine balance is stated to exert greater influence on gingival overgrowth compared to the direct effect of the drug on the regulation of extracellular matrix metabolism. the current study evaluated the effect of phenytoin on the regulation of collagen, lysyl oxidase and elastin in gingival fibroblasts.normal human gingival fibroblasts (hgfs) were obtained from 4 healthy chi...

The inflammasome is a cytoplasmic multiprotein complex that has recently been identified in immune cells as an important sensor of signals released by cellular injury and death. Analogous to immune cells, hepatic stellate cells (HSC) also respond to cellular injury and death. Our aim was to establish whether inflammasome components were present in HSC and could regulate HSC functionality. Monos...

Earthworms have a thin layer of cuticle which covers the whole body and serves as a general protective function. This cuticle has the characteristic wide angle x-ray diffraction pattern of collagen (1, 2) and has an amino acid composition characteristic of collagen (3). Much of the dry weight of this cuticle can be extracted by neutral salt or weak acid and purified as a collagen (4, 5). Earthw...

Submitted for the MAR08 Meeting of The American Physical Society Self assembled silicon nanowire Schottky junction assisted by collagen1 DIDIER STIEVENARD, IEMN DptISEN, BILLEL SAHLI, IEMN-Dpt ISEN, YANNICK COFFINIER, RABAH BOUKHERROUB, IRI FRE2963, OLEG MELNYK, IBL UMR8525, IEMN DPTISEN TEAM, IRI TEAM, IBL TEAM — We present results on self assembled silicon nanowire Schottky junction assisted ...

Glaucoma is an optic neuropathy that affects 60 million people worldwide. The main risk factor for glaucoma is increased intraocular pressure (IOP), this is currently the only target for treatment of glaucoma. However, some patients show disease progression despite well-controlled IOP. Another possible therapeutic target is the extracellular matrix (ECM) changes in glaucoma. There is an accumul...

BACKGROUND While cannabinoids have been shown to ameliorate liver fibrosis, their effects in chronic pancreatitis and on pancreatic stellate cells (PSC) are unknown. METHODOLOGY/PRINCIPAL FINDINGS The activity of the endocannabinoid system was evaluated in human chronic pancreatitis (CP) tissues. In vitro, effects of blockade and activation of cannabinoid receptors on pancreatic stellate cell...