OBJECTIVE To estimate in a cross sectional analysis the degree of colinearity among the disease activity measures more commonly used in juvenile chronic arthritis (JCA). METHODS This study assessed in a single clinical evaluation three subjective variables, three measures of functional capacity, eight articular indices, and two laboratory indicators of systemic inflammation in 55 consecutive ...

Polyketides are widespread biologically active heteropolymers produced by ‘assembly line’-like multi-protein complexes formed by modular polyketide synthases (PKS). The nature of the polyketide product is encoded in the order of particular types of PKS proteins along the assembly line, suggesting that the diversity of polyketides derives from the combinatorial rearrangement of complexes formed ...

Polyketides are widespread, biologically active heteropolymers assembled by complexes of modular polyketide synthase(PKS) proteins. We implement a model of this system and explore its evolutionary behavior while subject to recombination in a changing environment. Under appropriate population parameters the combinatorial exploration of novelty allows a finite population to maintain high fitness ...

introduction: the key characteristics of positron emission tomography (pet) are its quantitative capability and its sensitivity, which allow the in vivo imaging of biochemical interactions with small amounts of tracer concentrations. therefore, accurate quantification is important. however, it can be sensitive to several physical factors. the aim of this investigation is the assessment of the e...

Introduction: The key characteristics of positron emission tomography (PET) are its quantitative capability and its sensitivity, which allow the in vivo imaging of biochemical interactions with small amounts of tracer concentrations. Therefore, accurate quantification is important. However, it can be sensitive to several physical factors. The aim of this investigation is the assessment of the e...