Background Human coagulation factor IX is a 57kDa plasma serine protease made in Liver which plays a vital role in the blood coagulation cascade. FIX deficiency causes severe disorder Hemophilia B or Christmas disease. Nowadays, recombinant proteins have important roles in treatment of diseases. Although, cultivated mammalian cells because of their ability for producing properly folded protein ...

The range of hosts that parasites can infect is a key determinant of the emergence and spread of disease. Yet, the impact of host range variation on the evolution of parasite genomes remains unknown. Here, we show that codon optimization underlies genome adaptation in broad host range parasites. We found that the longer proteins encoded by broad host range fungi likely increase natural selectio...

Codon Optimization helps increasing immuno-stimulatory nucleotide motifs or decreasing immunesuppresive motifs in DNA expression vectors. This enhances the efficiency of DNA vaccinations. In this paper, we investigate the existing Pattern Matching algorithm for Codon Optimization and try to rewrite the algorithm in MapReduce programming model for execution speed-up and faster computation. Keywo...

SUMMARY Codon optimization has been widely used for designing synthetic genes to improve their expression in heterologous host organisms. However, most of the existing codon optimization tools consider a single design criterion and/or implement a rather rigid user interface to yield only one optimal sequence, which may not be the best solution. Hence, we have developed Codon Optimization OnLine...

the alternative use of non-selective herbicides in different years will reduce the possibility of weeds resistance to herbicide by avoiding the crops constant exposure to herbicide selection pressure. the photoperiod-sensitive genic male sterile (pgms) rice with herbicide resistance will be convenient to the mechanization of hybrid seed production and weed control. in order to develop double he...

BACKGROUND The sequences of wild-isolate strains of Human Immunodeficiency Virus-1 (HIV-1) are characterized by low GC content and suboptimal codon usage. Codon optimization of DNA vectors can enhance protein expression both by enhancing translational efficiency, and by altering RNA stability and export. Although gag codon optimization is widely used in DNA vectors and experimental vaccines, th...

UNLABELLED Numerous software applications exist to deal with synthetic gene design, granting the field of heterologous expression a significant support. However, their dispersion requires the access to different tools and online services in order to complete one single project. Analyzing codon usage, calculating codon adaptation index (CAI), aligning orthologs and optimizing genes are just a fe...