background: bladder cancer (bc) is the most commonly diagnosed genitourinary cancer in iran, presented in both men and women. bc is a multifactorial trait resulting from the complex interaction between several genes and environmental factors. long stress-induced non-coding transcript 5 (lsinct5), a member of the long non-coding rnas, is abundantly expressed in high proliferative cells, as well ...

background: bladder cancer (bc) is the most common genitourinary cancer in iranians with an unclear etiopathogenesis. long stress induced non-coding transcript 5 is a member of the 12-member family of long non-coding rnas, which is abundantly expressed in higher proliferative cells, as well as the cell vulnerable to cellular stress in response to chemical carcinogens. as variations in long non-...

background: bladder cancer is one of the most common cancers in the world with considerably higher frequency among men than women. treatment of the disease is possible according to early diagnosis, so identifying useful markers is very important. lsinct5 (long stress-induced non-coding transcript 5) is a stress-regulated lncrna involved in response to oxidative stress, also in cell proliferatio...

Introns qualify as Noncoding nucleotide sequences. In splicing, some segments of the RNA transcript (introns) are eliminated, other (exons) joining together in formation coding RNAs (mRNA, rRNA and tRNA). Also, Non-coding genes parts intronic. On average, there 7.8 introns 8.8 exons per human gene. Single polymorphisms (SNPs) existed various positions through gene, promoters, alternating region...

The EIF4E gene spans >50 kbp and contains 8 exons, one of them being alternative. It codes for the major, 4749 nucleotides long transcript variant 1, that codes 217 aa long protein. The longest transcript, variant 2 (4842 nucleotides) contains an additional in-frame exon in 3' coding region compared to variant 1 and codes for a protein (248 aa long, isoform 2) with a longer cterminus compared t...

The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) is abundantly expressed in latently infected sensory neurons. In small animal models of infection, expression of the first 1.5 kb of LAT coding sequences is necessary and sufficient for wild-type reactivation from latency. The ability of LAT to inhibit apoptosis is important for reactivation from latency. Within the fir...

Summary: SOX2 overlapping transcript (SOX2OT) is a long non-coding RNA associated with cancer pathogenesis. It contributes to a variety of cellular functions and recent evidence propounds its association with autophagy process. It has been showed that SOX2OT can regulate the expression of different autophagy associated factors in human cells with different mechanisms, however more remains to ...

ERRgamma has 4 coding and 1 (presumed) non-coding transcript variants. ERRgamma transcript variant 1 (NCBI, NM_001438) is the longest isoform, while ERRgamma transcript variant 2 (NM_206594) utilizes an alternate 5' UTR and lacks the first 23 amino acids of the coding sequence of variant 1 (Heard et al., 2000). In 2006, a third splice variant (ERRgamma3, NM_206595) was identified (Kojo et al., ...