Unexplained intraoperative coagulopathies continue to be a diagnostic and therapeutic dilemma. The pathophysiology behind unexplained intraoperative coagulopathies is of great variety and complexity (preexisting coagulopathies, dilutional coagulopathy, interactions of medications etc.). We have shown in prospective studies that patients undergoing elective surgery who develop "unexplained" intr...

Coagulopathies cause a predisposition to thrombosis and therefore an increased risk of ischaemic stroke. Although the frequency of coagulopathies in patients with stroke is low, the yield for diagnosing coagulopathies is typically greatest in young patients, those with family history of thrombosis, those with repeated unexplained strokes and patients with no vascular risk factors, as Omer H T A...

The blood is a very complex organ in our body and coagulation, in particular, is coordinated by various mechanisms. It is known from experience that in order to truly learn and comprehend the different coagulation processes and disorders, most medical students take much time and great pains. The topic is often regarded as not comprehensible and very abstract. This article is supposed to provide...

INTRODUCTION The coagulation system involves a cascade of factors responsible for maintenance of haemostasis in the body. This system is not only made for forming clots but is also involved in tissue repair, defence against micro-organisms, autoimmune processes, arteriosclerosis, tumour growth and metastasis. Surgical procedures often cause imbalance of this system, leading to a tendency to eit...

Spontaneous pregnancy loss is often associated with aberrant maternal inflammation and systemic coagulopathies. However, the role of inflammation in the development of obstetric coagulopathies is poorly understood. Further, questions remain as to whether systemic coagulopathies are linked to placental haemostatic alterations, and whether these local alterations contribute to a negative foetal o...