objective(s): smoking opium/cigarette is a global health concern. the aim of this study was to examine learning and memory of rat male offsprings whose mothers had been exposed to either opium or morphine with nicotine during pregnancy. materials and methods: wistar rats were used for the experiments. in the female rats, opium, morphine and nicotine dependencies were induced by daily injections...

Background: Co-administration of anesthetics has been employed to decrease potential unpleasant effects associated with single drug. OBJECTIVES: This study was designed to evaluate the effects of co-administration of ketofol with diazepam or midazolam in healthy dogs. METHODS: Six adult mix-breed male dogs were used. After sedation with acepromazine (0.1 mg/kg), anesthesia was induced with kete...

background: previous studies have reported the antifertility activities of sulfonamides. this study was designed to evaluate the effects of co-trimoxazole and its co-administration with folic acid on ovarian tissue in female rats. methods: a total of 54 rats were randomly divided into 9 groups (n=6) . group i served as the control and group ii (vehicle) received saline. other groups, iii to ix,...

today it seems to be necessary to generate innovative ideas in social and economic section to comparative advantage in new business opportunities. therefore, this study aimed to compared the views of experts of sports management and co-administration experts on the development of small and medium sport enterprises in the form of cooperative, in order to achieve economic and social goals. this r...

noise induced hearing loss (nihl) is one of the most important occupational disease worldwide. nihl has been found potentiate by simultaneous carbon monoxide (co) exposure. free radicals have been implicated in cochlear damage resulted from the exposure to noise and due to the co hypoxia. this study examined whether α-tocopherol administration, as a free radical scavenger, causes the attenuatio...

Alzheimer is a progressive neurodegenerative disorder in which Oxidative stress plays a major role. The present study was designed to investigate Neuroprotective effect of Lornoxicam, Selegiline and co-administration of both drugs in Scopolamine induced cognitive impairment and neurodegeneration. Scopolamine (1.4mg/kg) was administered intraperitoniallyin male Wistar rats. Rectangular maze perf...

alzheimer is a progressive neurodegenerative disorder in which oxidative stress plays a major role. the present study was designed to investigate neuroprotective effect of lornoxicam, selegiline and co-administration of both drugs in scopolamine induced cognitive impairment and neurodegeneration. scopolamine (1.4mg/kg) was administered intraperitoniallyin male wistar rats. rectangular maze perf...

Background and Aims: Hepatotoxicity induced by Co-amoxiclav has been indicated in multiple studies. Thymol is the main constituent of the Thymus vulgaris essential oil that has antioxidant properties. Even though thymol can exhibit antioxidant activity in vivo models, there is a lack of evidence about the thymol’s effectiveness in drug-induced liver injury. Thus, the present study was conducted...

The aim of this study was to investigate the effect of ketamine and midazolam on preventing the development of morphine tolerance and dependence and withdrawal syndrome in mice. In the present study different groups of mice were received morphine (50 mg/kg, s.c.), morphine (50 mg/kg, s.c.) + ketamine (25, 50, 75 mg/kg, i.p.) , morphine (50 mg/kg , s.c.) + midazolam (0.5, 1, 2 mg/kg, i.p.) , mor...