congenital malformation (cm) will begin to emerge as one of the major childhood health problems .treatment and rehabilitation of children with congenital malformations are costly and complete recovery is usually impossible. the aim of this study was to determine frequency of cm in yazd central city of the islamic republic of iran to find out if there has been any difference in the rate and type...

Callosal anomalies are frequently associated with other central nervous system (CNS) and/or somatic anomalies. We retrospectively analyzed the clinical features of corpus callosal agenesis/hypoplasia accompanying other CNS and/or somatic anomalies. We reviewed the imaging and clinical information of patients who underwent brain magnetic resonance imaging in our hospital, between 2005 and 2012. ...

Hydranencephaly is a rare anomaly of the central nervous system (CNS)which charaderised by absence of the cerebral hemispheres. The etiologic hypotheses are numerous and the causal injuries have been thought to be vascular ocdusion. viral encephalitis and genetic abnormalities.

Limb bud (LB) and central nerve system (CNS) cells were prepared from 12.5 day old pregnant female Crj:CD (SD) rats and treated with olaquindox and vitamin A. Cytotoxicity and inhibition on differentiation were measured in each cell. Three doses of olaquindox (4, 21 and 100 mgkg) , and 0.2 and 75 mg/kg of vitamin A were administered to pregnant rat for 11 days from 6(th) to 16(th) of pregnancy....

OBJECTIVE Central nervous system (CNS) anomalies are the most common abnormalities of all malformations and can be diagnosed on routine prenatal ultrasonography (US). We aimed to find out fetal CNS anomaly rate in our clinic which is the referral center in the region. METHODS This is a retrospective study of 15000 pregnant women who were scanned for routine obstetric follow-up from January 20...

tumors of the central nervous system (cns), occur relatively frequently during the early years of life. they are the most common solid tumors of childhood and are second only to leukemia in overall cancer incidence and account for a high proportion of deaths. in different studied performed in several countries, astrocytomas and other gilomas (combined) account for half of the cns malignancies, ...

background: central nervous system (cns) relapse in acute lymphoblastic leukemia was significantly decreased due to the use of new chemotherapyeutic agents, intrathecal chemotherapy and cranial irradiation. the purpose of this study was to compare the effectiveness of intrathecal (it) cns chemotherapy alone versus combination of it chemotherapy with cranial irradiation for prevention of cns rel...

BACKGROUND The presence of a congenital anomaly is associated with increased childhood cancer risk, likely due to large effects of Down syndrome and chromosomal anomalies for leukemia. Less is known about associations with presence of non-chromosomal anomalies. METHODS Records of children diagnosed with cancer at <20 years of age during 1984-2013 in Washington State cancer registries were lin...

thrombin is a multifunctional enzyme which has key roles in coagulation cascade and inflammatory events. the pro-inflammatory functions of thrombin occur by different mechanisms including increasing mast cell degranulation, up-regulating the expression of cell adhesion molecules (cams) and promoting the secretion of inflammatory chemokines and cytokines. dysregulated signaling functions of thro...

OBJECTIVE To establish the adenosine deaminase (ADA) activity in women who had been pregnant with a child suffering from central nervous system (CNS) anomaly. METHODS The study group comprised 68 women who had been pregnant with an affected child, and 68 controls matched for age, gestational age and body mass index. Maternal venous blood was collected for measurement of ADA levels. We defined...