Two recent studies have demonstrated that clotrimazole, a well-known potential antifungal agent, inhibits the in vitro growth of chloroquine-resistant strains of the malaria parasite, Plasmodium falciparum. In a previous study, we suggested that clotrimazole acts as an anti-malarial agent by inhibiting heme catabolism in the malaria parasite and by enhancing heme-induced membrane damage. In thi...

BACKGROUND Clotrimazole is an antifungal imidazole derivative showing anti- neoplastic effect in some tumors, but its anticancer potential is still unclear in oral squamous cell carcinoma (OSCC). The aim of this study was to evaluate the antitumor effect of clotrimazole, and to investigate the possible mechanism of clotrimazole-mediated antitumor activity in OSCC. METHODOLOGY In vitro experim...

Polymer encapsulation of drugs is conventionally used as a strategy for controlled delivery and enhanced stability. In this work, a novel encapsulation approach is demonstrated, in which the organic molecule clotrimazole is enclosed into wrinkles of defined sizes. Having defined wrinkles at the drug/encapsulant interface, the contact between the encapsulating polymer and the drug can be improve...

Polymer encapsulation of drugs is conventionally used as a strategy for controlled delivery and enhanced stability. In this work, a novel encapsulation approach is demonstrated, in which the organic molecule clotrimazole is enclosed into wrinkles of defined sizes. Having defined wrinkles at the drug/encapsulant interface, the contact between the encapsulating polymer and the drug can be improve...

BACKGROUND Clotrimazole is an azole derivative with promising anti-cancer effects. This drug interferes with the activity of glycolytic enzymes altering their cellular distribution and inhibiting their activities. The aim of the present study was to analyze the effects of clotrimazole on the growth pattern of breast cancer cells correlating with their metabolic profiles. METHODOLOGY/PRINCIPAL...

OBJECTIVE To compare the efficacy and safety of terbinafine 1% cream and clotrimazole 1% cream in the treatment of tinea pedis. DESIGN Multicentre, double blind parallel group study. SETTING 32 general practices and one hospital. PATIENTS 256 patients with mycologically confirmed tinea pedis. Of the 211 patients evaluable, 107 were randomised to terbinafine (75 male, 32 female; mean (rang...

The in vitro antifungal activity of clotrimazole (Bay b 5097) was compared with those of amphotericin B, griseofulvin, nystatin, and pyrrolnitrin. The inhibitory activity of clotrimazole against most systemic pathogens was comparable to that of amphotericin B; minimal inhibitory concentrations of the two drugs for Blastomyces dermatitidis, Histoplasma capsulatum, Sporothrix schenckii, Cryptococ...

Background Microparticles are one of drug delivery systems designed for sustained and controlled release drugs a long period time. Clotrimazole is broad-spectrum antifungal agent, which generally used treatment Candida albicans others fungal infections. Objective The present study aims to fabricate microparticles using beeswax (lipophilic coating) polyethylene glycol (hydrophilic coating). Meth...

A total of 80 patients were equally randomized to receive a single dose of 6.5% tioconazole ointment or a 3-day course of 100-mg clotrimazole vaginal tablets for the treatment of vulvovaginal candidiasis. Of the 32 evaluable patients treated with tioconazole, 27 (84%) remained asymptomatic 4 weeks posttreatment, compared with 28 of 33 patients (85%) treated with clotrimazole. A total of 34 pati...

Azoles are one of the most widely used drugs to treat fungal infections. To further understand response azoles, we analyzed MAPK circuitry model yeast Saccharomyces cerevisiae that operates under treatment with these antifungals. Imidazoles, and particularly clotrimazole, trigger deeper changes in phosphorylation than triazoles, involving a reduction signaling through mating pathway activation ...