The plasma and salivary disposition of closantel and rafoxanide were examined following intravenous administration in adult sheep. Two studies were conducted with rafoxanide at 7.5 mg/kg and 1 with closantel using 2 doses (5 and 15 mg/kg). The pharmacokinetic profile of both drugs in plasma were best described by a 2-compartmental model with 1st-order rate constants. Plasma disposition of closa...

Control of Fasciola hepatica infection in livestock is based on annual treatment using flukicides such as triclabendazole, albendazole and closantel. However, triclabendazole resistant F. hepatica populations are emerging worldwide and resistance is emerging to albendazole, whereas it has until now never been described for closantel. In Sweden, a topical formulation containing a combination of ...

On the strength of a complaint of suspected resistance to closantel, a field strain of Haemonchus contortus was isolated from sheep on a farm near Pretoria and tested for resistance to the remedy, both without exposure to closantel in the laboratory (designated the "unselected" substrain of the parasite) and after a single selection with closantel (called the "selected" substrain). For comparat...

ABSTRACT In this paper, the square-wave adsorptive stripping voltammetric (SWAdSV) determination of the veterinary drug closantel using a renewable silver amalgam film electrode (Hg(Ag)FE) is presented. As observed in SWAdSV, closantel provided one well-shaped reduction peak suitable for analytical purposes at potential ca. -1.4 V in the Britton-Robinson (B-R) buffer at pH 7.0. At optimal condi...

In mid-March 2015 approximately 400 September 2014 drop Dorset cross Merino lambs from a property near Hill End on the central tablelands of NSW were shorn and drenched with 10 ml of a commercial closantel and abamectin mix (Genesis Xtra, Ancare containing 1g/L abamectin and 50g/L closantel, recommended dose 1 ml/5kg bodyweight, equivalent to 10mg closantel/kg). Two weeks later, several lambs w...

The stability and the partitioning of closantel and rafoxanide in ruminal fluid (RF) was examined in vitro. Stability was evaluated in two studies in a ruminal fluid-artificial saliva (RF-AS) mixture containing either drug. Drug concentrations were measured in samples collected sequentially from four batches of RF-AS fortified with either closantel or rafoxanide in one study and in four separat...

Rivero R., Matto C., Soares M.P. & Adrien M.L. 2015. Accidental and experimental Closantel intoxication in Uruguayan sheep. Pesquisa Veterinária Brasileira 35(7):599-604. Laboratorio Regional Noroeste “Dr. Miguel C. Rubino”, Dirección de Laboratorios Veterinarios of Ministerio de Ganaderia, Agricultura y Pesca, Ruta 3, Km 369, Cx. Postal 57.037, CP 60.000, Paysandú, Uruguay. E-mail: rrivero@mga...

Clinically healthy adult black Bengal female goats were used to investigate the pharmacokinetics of closantel following intravenous administration (10 mg/kg) both in healthy and in liver damaged goats. Induction of liver damage was done by subcutaneous injection of carbontetrachloride at 0.75 mL/kg on three occasion at 48 h interval. After administration of drug, blood samples were collected in...

INTRODUCTION The halogenated salicylanilides are a group of compounds developed mainly for their antiparasitic activity in animals. Closantel and rafoxanide, which represent the most important drugs in this group, are used extensively for the control of Haemonchus spp. and Fasciola spp. infestations in sheep and cattle and Oestrus ovis in sheep in many parts of the world. Clinical signs of clos...

The L3-stage-specific chitinase OvCHT1 has been implicated in the development of Onchocerca volvulus, the causative agent of onchocerciasis. Closantel, a known anthelmintic drug, was previously discovered as a potent and specific OvCHT1 inhibitor. As closantel is also a known protonophore, we performed a simple scaffold modulation to map out the structural features that are relevant for its ind...