background: infertility affects about 10-15% of reproductive-age couples. about half the causes of infertility are female related and approximately 40% of the cases are caused by anovulation, mostly in pco women. objective: this study was conducted to determine and compare the effects of two drug treatment regimens: higher dose of clomiphene and a combination of lower dose of clomiphene and tam...

objective: to determine the efficacy of ovarian drilling in pco patients who failed to achieve pregnancy with medical treatment. methods and main results: 75 patients with a diagnosis of pco of whom 48(64%) were primary infertile and 27(36%) were secondary infertile were clomiphene resistant. the other methods like bromocriptin, gonadotropins, gnrh -a and metformin had been given to these patie...

Objective This study was performed to compare the success level of laparoscopic ovarian drillind by means of standard and dose-adjusted (on the basis of ovarian volume) treatment methods among infertile clomiphene resistant PCO women. MaterialsAndMethods This randomized clinical trial was conducted on infertile clomiphene citrate resistant PCOS women in the Gynecology department of Imam Reza Ho...

Background: Clomiphene citrate (CC) is still holding its place as the first-line treatment for induction of ovulation in polycystic ovary syndrome (PCOS) patients.  Objective: to assess effect extended clomiphene on pregnancy outcomes resistant PCOS. Patients and methods: this study was conducted 48 PCO patients with CC resistance attended Obstetrics Gynecology Outpatient Clinic at Menoufia U...

Objective: To determine the efficacy of ovarian drilling in PCO patients who failed to achieve pregnancy with medical treatment. Methods and Main Results: 75 patients with a diagnosis of PCO of whom 48(64%) were primary infertile and 27(36%) were secondary infertile were clomiphene resistant. The other methods like bromocriptin, gonadotropins, GnRH -a and metformin had been given to these ...

Background & Objective: Clomiphene resistance is an important problem among women with Polycystic Ovarian Disease (PCOD) suffering from infertility. Recognition of the causes would result in better prognosis these patients. This study was performed to determine different PCOD phenotypes and their effects on clomiphene infertile women.Materials Methods: In this descriptive-comparative cross-sect...

background: in patients with anovulatory infertility the first choice of treatment for ovulation induction is an antiestrogen, most commonly clomiphene citrate (cc). however, 20-25% of the women are resistant to cc and do not ovulate perhaps due to antiestrogenic mechanism of the cc action, which involves long-lasting estrogen receptor (er) depletion. objective: the objective of the study was t...

background: polycystic ovary syndrome (pcos) is associated with approximately 75% of women who suffer from infertility due to anovulation. additionally, around 20– 25% of anovulatory women with pcos do not respond at all to clomiphene citrate and are considered to be “clomiphene– resistant”. aromatase inhibitors have been suggested as an alternative treatment to clomiphene as the discrepancy be...

Background To evaluate the effect of metformin on ovulation and pregnancy rate in clomiphene citrate resistant women with polycystic ovary syndrome (PCOS). MaterialsAndMethods In this clinical trial each patient, regarding her previous resistance to Clomiphene, served as her own control. A total of 35 clomiphene citrate resistant PCOS patients, referring to Royan institute were studied. Clomiph...