background: clofibrate is a pharmacological agent, which affects the lipid metabolism. this compound could be involved in bilirubin accumulation and excretion process. therefore, this study aimed to evaluate the effect of oral clofibrate intake on total serum bilirubin (tsb) of neonates hospitalized at khatam hospital. methods: this clinical trial was conducted on 73 neonates with hyperbilirubi...

BACKGROUND AND AIMS Clofibrate, an established PPARα ligand, has recently been shown to have anticancer activity yet its mechanisms of action remain to be characterized. This study examined the effect of clofibrate on heme oxygenase-1 (HO-1) gene expression in A2780 (human ovarian cancer) and DU145 (human prostate cancer) cells. METHODS AND RESULTS We demonstrate that clofibrate induces HO-1 ...

Background   Lipoprotein lipase activity can be increased by clofibrate. Clofibrate is used to reduce serum triglyceride level in adults. The aim of this study was to determine the effect of clofibrate on serum triglyceride and cholesterol level after administration of intravenous lipid in very low birth weight neonates. Method In a randomized double blind placebo – controlled study, 60 very lo...

References GREEN, K.C. & MARGARETZ, G. (1967) Long-term follow-up of multicentre trial of ethyl-a-p-chlorphenoxyisobutyrate (Clofibrate, 'Atromnid'-S) and Clofibrate Plus Androsterone ('Atromid'). Progress in Biochemical Pharmacology, 2, 378. KATSILAMBROS, BRAATEN, J.B., FERGUSON, D. & BRADLEY, R.F. (1972) Muscular syndrome after clofibrate. New England Journal of Medicine, 286, 1 10. LANGER, T...

Normal subjects and patients with antidiuretic hormone (ADH) deficiency were studied to determine the mechanism of the antidiuretic action of clofibrate. Before clofibrate treatment, the patients' ability to concentrate urine with a standardized dehydration procedure correlated with the amount of ADH which was excreted. During clofibrate administration all six patients with ADH deficiency devel...

Fibrates are widely used hypolipidemic agents that activate the peroxisome proliferator-activated receptor a (PPARalpha) and regulate the expression of many genes involved in lipid metabolism. We studied the mechanism of the effect of clofibrate on cholesterol homeostasis. Rats were fed with chow containing clofibrate, cytochrome P-450 inhibitor ketoconazole, or clofibrate plus ketoconazole. Co...

BACKGROUND Nitric oxide (NO) regulates renal proximal tubular (PT) Na+ handling through modulation of Na+-K+ ATPase. Peroxisome Proliferator Activated Receptor alpha (PPARalpha), a nuclear transcription factor, is expressed in PTs and has been reported to influence NO generation/activity in renal tissues. This study tested the hypothesis that PPARalpha interacts with NO and thereby affects rena...

Glucose-6-phosphate dehydrogenase (G6PD) deficiency may cause severe hyperbilirubinemia with bilirubin encephalopathy unless intervention is initiated. The aim of this study was to assess the efficacy of clofibrate in full term G6PD deficient neonates with jaundice. A randomized clinical trial study was performed in two groups of full-term G6PD deficient jaundiced neonates (clofibrate treated g...