breast carcinoma is the major cause of cancer-related death in women. the incidence of this carcinoma is rising and there are many attempts to decrease this problem. the aim of this study was detection of full-length cytokeratin 19 (ck19) mrna, in peripheral blood and tissue of breast cancer patients in early stage of cancer. in this study, rt-pcr (reverse transcriptase-polymerase chain reactio...

Cytokeratin 8 (CK8) and cytokeratin 19 (CK19) is a specific cytoskeletal component of simple epithelia, including bronchial epithelial cells. We hypothesized that CK8 or CK19 released from epithelial cells may bind to and cause damage to extracellular matrixes through binding of anti-CK8 or anti-CK19 autoantibodies. In the present study, bindings of recombinant human CK8 and CK19 to laminin (bo...

Background & AimsPeribiliary glands (PBGs), clusters of epithelial cells residing in the submucosal compartment extrahepatic bile ducts, have been suggested as biliary stem/progenitor cell niche; however, evidence to support this claim is limited because a lack PBG-specific markers. We therefore sought identify markers investigate potential role PBGs niches, well an origin cancer.MethodsWe exam...

background: carcinomas of the thyroid follicular epithelium are the most common cancers of the endocrine system. in the diagnosis of thyroid nodules and tumors, the gold standard is histological evaluation. in cases which have morphological overlap,immunohistochemistry is needed for differential diagnosis. the purpose of this study is to investigate the expressions of cd56,hbme?1, cytokeratin 1...

BACKGROUND CK19-2G2, a new fragment of cytokeratin 19, is a potential tumor marker for diagnosing lung cancer. The preoperative level of serum CK19-2G2 has been demonstrated to be associated with tumor metastasis and survival of breast cancer patients. This study investigated the postoperative dynamic changes in serum CK19-2G2 levels and its clinical significance in lung cancer patients. MATE...

Staging by sentinel node (SN) biopsy is the standard procedure for clinically node-negative breast cancer patients. Intra-operative analysis of the SN allows immediate axillary lymph node (ALN) dissection in SN positive patients, but a quick, reliable and reproducible method is lacking. We tested the suitability of a quantitative cytokeratin 19 (CK19) mRNA one step nucleic acid amplification (O...

BACKGROUND AND AIMS Cytokeratin19 positive (CK19+) hepatocellular carcinoma (HCC) is thought to derive from liver progenitor cells (LPC). However, whether peritumoralductular reaction (DR) differs between CK19+ and CK19 negative (CK19-) HCC patients remains unclear. MATERIAL AND METHODS One hundred and twenty HBV-related HCC patients were enrolled in this study. Clinicopathological variables ...

Expression of cytokeratin (CK) profiles in primary signet-ring cell carcinoma (SRCC) of the stomach and colorectum have rarely reported; only two such studies are present in the world literature. Herein, an immunohistochemical study on cytokeratin (CK) expression was performed in 42 cases of primary SRCC of the stomach (30 cases) and colorectum (12 cases). SRCC was defined as an adenocarcinoma ...

Background: Intra-operative molecular diagnostic assays are currently used for the detection of lymph node metastases. The objective of this study was to find new biomarkers to improve diagnostic accuracy in the detection of metastatic axillary lymph nodes in breast cancer patients. Methods: We applied an absolute quantitative real-time RT-PCR to quantitate the expression of CK19, KLK11, and CL...

Dendritic cells (DCs) as 'professional' antigen-presenting cells (APCs) initiate and regulate immune responses to various antigens. DC-based vaccines have become a promising modality in cancer immunotherapy. Cytokeratin 19 (CK19) protein is expressed at high levels in lung cancer and many other tumor cells, suggesting CK19 as a potential tumor‑specific target for cancer immune therapy. We const...