Let H be a Hilbert space. Given a bounded positive definite operator S on H, and a bounded sequence c = {ck}k∈N of non negative real numbers, the pair (S, c) is frame admissible, if there exists a frame {fk}k∈N on H with frame operator S, such that ‖fk‖ 2 = ck, k ∈ N. We relate the existence of such frames with the Schur-Horn theorem of majorization, and give a reformulation of the extended ver...

INTRODUCTION Methotrexate is a drug that has shown anti-ischemic effects in animal studies and positive results in heart failure clinical trials. METHODS We will randomly assign 80 patients with acute myocardial infarction to receive methotrexate (0.05 mg/kg bolus followed by 0.05 mg/kg/h for 6 h) or matching placebo. The primary outcome will be the area under the curve (AUC) for creatine kin...

T cells navigate complex microenvironments to initiate and modulate antigen-specific immune responses. While recent intravital microscopy study revealed that migration of T cells were guided by various tissue microstructures containing unique nanoscale topographical structures, the effects of complex nanotopographical structures on the migration of T cells have not been systematically studied. ...

The creatine kinase (CK) phosphagen system is fundamental to cellular energy homeostasis. Cardiomyocytes express three CK isoforms, namely the mitochondrial sarcomeric CKMT2 and the cytoplasmic CKM and CKB. We hypothesized that augmenting CK in vitro would preserve cell viability and function and sought to determine efficacy of the various isoforms. The open reading frame of each isoform was cl...

This paper explores models for arithmetics in substructural logics. In the existing literature on substructural arithmetic, frame semantics for substructural logics are absent. We will start to fill in the picture in this paper by examining frame semantics for the substructural logics C (linear logic plus distribution), R (relevant logic) and CK (C plus weakening). The eventual goal is to find ...

Co-expression of cytokeratin (CK) pairs has been found to be associated with specific epithelial cell types whose expressions are developmentally regulated. In the prostate, CK 8 and 18 have been identified as luminal cell-specific markers, and CK 5 and 15 have been identified as basal cell-specific markers. In this study, we report the cloning and sequencing of a full-length CK 8 cDNA (1.9 kil...

Pycnodysostosis is a rare autosomal recessive skeletal dysplasia characterized by short stature, osteosclerosis, acroosteolysis, bone fragility, and skull deformities. Recently, mutations in the gene encoding cathepsin K (CK), a lysosomal cysteine protease localized exclusively in osteoclasts, were found to be responsible for this disease. We analyzed genomic DNA from four unrelated Japanese pa...