نتایج جستجو برای: circuit bistability

تعداد نتایج: 116875  

2016
Teng Wang Chenzi Jin Fangting Li School of Life Sciences Peking University Beijing China. School of Physics China. Center for Quantitative Biology China.

Fission yeast G2/M transition is regulated by a biochemical reaction networks which contains four components: Cdc13, Cdc2, Wee1, and Cdc25. This circuit is characterized by the ultrasensitive responses of Wee1 or Cdc25 to Cdc13/Cdc2 activity, and the bistability of Cdc2 activation. Previous work has shown that this bistability is governed by phosphorylation energy. In this article, we developed...

Journal: :Molecular Biology of the Cell 2021

Journal: :Physical biology 2015
Imre Májer Amirhossein Hajihosseini Attila Becskei

Bistability underlies cellular memory and maintains alternative differentiation states. Bistability can emerge only if its parameter range is either physically realizable or can be enlarged to become realizable. We derived a general rule and showed that the bistable range of a reaction parameter is maximized by a pair of other parameters in any gene regulatory network provided they satisfy a ge...

Journal: :Neural networks : the official journal of the International Neural Network Society 2013
Jordan D. T. Engbers Fernando R. Fernandez Ray W. Turner

The output of cerebellar Purkinje cells has been characterized extensively and theories regarding the role of simple spike (SS) and complex spike (CS) patterns have evolved through many different studies. A bistable pattern of SS output can be observed in vitro; however, differing views exist regarding the occurrence of bistable SS output in vivo. Bistability in Purkinje cell output is characte...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2001
Y Manor F Nadim

When depressing synapses are embedded in a circuit composed of a pacemaker neuron and a neuron with no autorhythmic properties, the network can show two modes of oscillation. In one mode the synapses are mostly depressed, and the oscillations are dominated by the properties of the oscillating neuron. In the other mode, the synapses recover from depression, and the oscillations are primarily con...

2013
S. B. Cahn S.G.J. Mochrie

Two synthetic gene circuits – the genetic toggle switch and the repressilator – are discussed in the context of an educational module on gene circuits and feedback that constitutes the final topic of a year-long introductory physics sequence, aimed at biology and premedical undergraduate students. The genetic toggle switch consists of two genes, each of whose protein product represses the other...

Journal: :Physical review letters 2010
Lev S Bishop Eran Ginossar S M Girvin

We analyze the Jaynes-Cummings model of quantum optics, in the strong-dispersive regime. In the bad-cavity limit and on time scales short compared to the atomic coherence time, the dynamics are those of a nonlinear oscillator. A steady-state nonperturbative semiclassical analysis exhibits a finite region of bistability delimited by a pair of critical points, unlike the usual dispersive bistabil...

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