Background: Pseudomonas aeruginosa biofilm is one of the problems in antibiotic treatment infections. Nanomedicines, such as chitosan (CS) can carry multiple drugs and improve therapeutic effects antibiotics. Objectives: This study aimed at synthesis characterization ciprofloxacin-loaded nanoparticles for eradication P. aeroginosa biofilm. Methods: Cipro-CS microparticles were prepared by ionic...

Ciprofloxacin is the substrate for a multidrug resistance-related protein (MRP)-like multidrug transporter in J774 mouse macrophages, which also modestly affects levofloxacin but only marginally affects garenoxacin and moxifloxacin (J.-M. Michot et al., Antimicrob. Agents Chemother. 49:2429-2437, 2005). Two clones of ciprofloxacin-resistant cells were obtained by a stepwise increase in drug con...

conclusions minimum biofilm eradication values of ciprofloxacin obtained in the study are close to the values of the minimal inhibition concentration (mic). results all tested strains formed a biofilm. a value of 1.0 μg/ml ciprofloxacin is mbe50 for the strains of both tested species. an mbe90 value of ciprofloxacin for isolates of p. vulgaris was 2 μg/ml and for p. mirabilis was 512 μg/ml. mat...

objective(s) extensive use of quinolones has been associated with raising level of resistance. in the current, we focused on assessing the prevalence of escherichia coli resistance to quinolones and frequency of qnra, qnrb and qnrs in non esbls (extended spectrum beta-lactamases) and esbls producing e. coli with blashv and blatem. materials and methods one hundred and fifty e. coli isolates wer...

OBJECTIVE To compare the efficacy of subconjunctival injection of a combination of triamcinolone and ciprofloxacin hydrochloride, 2 mg/0.1 mL, in a controlled-release system (DuoCat) with that of ciprofloxacin hydrochloride, 0.3%, eyedrops for infection prophylaxis. METHODS Rabbit eyes were injected subconjunctivally with a combination of triamcinolone and ciprofloxacin hydrochloride, 2 mg/0....

a rapid, simple and sensitive high-performance liquid chromatography method was developed for determination of ciprofloxacin in plasma by means of ultraviolet detection. ofloxacin was used as an internal standard and separation carried on a novapak c18 column using a mobile phase of 0.01 m phosphate buffer (ph =2.6): methanol (82: 18 v/v). extraction of drug was performed from plasma by liquid-...

With the aim of improving the solubility of ciprofloxacin, polybasic organic acids were utilized to react with ciprofloxacin in different stoichiometric proportions. The use of the solvent drop grinding (SDG) method, as well as the solvent evaporation method, resulted in the crystalline salts ciprofloxacin/fumaric acid (1:1, 2:1), ciprofloxacin/maleic acid (1:1) and ciprofloxacin/citric acid (2...

The efficacy and safety of sequential intravenous/oral ciprofloxacin in moderate to severe respiratory tract infections (RTI) were compared with those of ceftazidime in a prospective clinical trial. Sixty-six patients received IV ciprofloxacin (200 to 300 mg twice daily), followed by oral ciprofloxacin (500 mg twice daily). Fifty-six patients received intravenous ceftazidime (1 to 2 g two to th...

The ethcacy and safety of sequential intravenous/oral ciprofloxacin in rnoderate to severe respiratory tract infections (RTI) were cornpared with those of ceftazidirne in a prospective clinical trial. Sixty-six patients received IN ciprofloxacin (200 to 300 rng twice daily), followed by oral ciprofloxacin(500 rng twice daily). Fifty-six patients received intravenous ceftazidime (1 to 2 g two to...

BACKGROUND AND OBJECTIVES Phosphate binders such as calcium salts or sevelamer, a cationic polymer, can markedly reduce absorption of oral ciprofloxacin. This randomized, open-label, two-way, crossover study examined the influence of the cation lanthanum on systemic ciprofloxacin exposure after oral administration. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS Twelve patients randomly receive...